DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt50B3 and Ugt2b37

DIOPT Version :9

Sequence 1:	NP_001260710.1	Gene:	Ugt50B3 / 246614	FlyBaseID:	FBgn0050438	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_001007265.4	Gene:	Ugt2b37 / 29623	RGDID:	3937	Length:	530	Species:	Rattus norvegicus

Alignment Length:	503	Identity:	142/503 - (28%)
Similarity:	237/503 - (47%)	Gaps:	52/503 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 SHKIPFWELAKGLISRGHNITFLSGFPADFNI-------EGLLEVTPAGL---------VEYIHN 79
            ||.:....:...|:.|||.:|.|.  |:.:.:       :...|..|..:         ::.:..
  Rat    34 SHWMNIKTILDELVQRGHEVTVLK--PSAYYVLDPKKSPDLKFETFPTSVSKDELEKYFIKLVDA 96

  Fly    80 YT---------NWDLLGSRMAGEMPIKPWDGLRYAFESC-DAMLRDSETKELTKKSFDLAILD-- 132
            :|         ::..|...|..|..       .|....| ||:.......:|.:..||:.:.|
  Rat    97 WTYELQRDTCLSFSPLLQNMMDEFS-------DYYLSVCKDAVSNKQLMAKLQESKFDVLLSDPV 154

  Fly   133 GAFPECFLGLMYDFKIPFMYINTVGFYTGSISTAGN---PVSYAITPNFYSRFTDTMNLYERAIN 194
            .|..|....:::   |||:|............::|.   |.||  .|...|.....|...:|..|
  Rat   155 AACGELIAEVLH---IPFLYSLRASPGHKIEKSSGRFILPPSY--VPVILSGLGGQMTFIDRVKN 214

  Fly   195 -TAMQIGQTLMHMYVMRRTHLVMREHLGTQIPHPYEMSRNVSFILQNGHAVLSYPRAFNPNVAEV 258
             ..|.......||:..:.......|.||........|.:...::::: :..|.:|....|||..:
  Rat   215 MICMLYFDFWFHMFNAKNWDPFYTEILGRPTTLAETMGKAEMWLIRS-YWDLEFPHPTLPNVDYI 278

  Fly   259 ACIHCRPARKLPRNLEEFIGASGASGFIYVSMGSSVKAANMPEALRHMLVKTFARLPYHVLWKYE 323
            ..:.|:||:.||:::|:|:.:||..|.:..|:||.|  ::|.|...:.:....|::|..||||::
  Rat   279 GGLQCKPAKPLPKDIEDFVQSSGEHGVVVFSLGSMV--SSMTEEKANAVAWALAQIPQKVLWKFD 341

  Fly   324 GSSTDIKDITSNVKLSRWLPQQDILGHPKLRAFVTHGGLLSMFETVYHGVPVVTMPVFCDHDVNS 388
            |...  ..:..|.::.:||||.|:|||||.:|||||||...::|.:|||:|::.:|:|.:...|.
  Rat   342 GKIP--ATLGPNTRVYKWLPQNDLLGHPKTKAFVTHGGANGVYEAIYHGIPMIGIPMFGEQHDNI 404

  Fly   389 AKAEVDGYAIKLDLQTLSANQLYKAIMKVIHNPRYRNSARHRQKLFLDQRSTALDTAIYWTEYVL 453
            |.....|.|:.|:::|:|.:.|:.|:.:||:||.|:.:|.....:..||....||.||:|.|||:
  Rat   405 AHMVAKGAAVTLNIRTMSKSDLFNALKEVINNPFYKKNAMWLSTIHHDQPMKPLDKAIFWIEYVM 469

  Fly   454 RHNGAYHLQTPSRNMTWWQYYLLDVVAVYLILLYVL-ILALRRIDFPY 500
            ||..|.||:....|:.|:||:.|||:...|..|.|: .||::...|.|
  Rat   470 RHKRAKHLRPLGHNLPWYQYHSLDVIGFLLACLAVIAALAVKCFLFIY 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt50B3	NP_001260710.1	YjiC	28..434	CDD:224732	113/434 (26%)
Ugt50B3	NP_001260710.1	egt	<172..479	CDD:223071	102/307 (33%)
Ugt2b37	NP_001007265.4	UDPGT	24..527	CDD:278624	142/503 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm44525
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.810