DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt50B3 and Ugt2b7

DIOPT Version :9

Sequence 1:	NP_001260710.1	Gene:	Ugt50B3 / 246614	FlyBaseID:	FBgn0050438	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_775445.2	Gene:	Ugt2b7 / 286989	RGDID:	708417	Length:	529	Species:	Rattus norvegicus

Alignment Length:	561	Identity:	147/561 - (26%)
Similarity:	251/561 - (44%)	Gaps:	90/561 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 WSCGTLAADILMATQGGTKSHKIPFWELAKG-----------LISRGHNITFL------------ 53
            |....|...|....:.| ...|:..|.|...           |:.|||.:|.|
  Rat     5 WISALLLLQISFCFRSG-NCGKVLVWPLEYSHWMNLKIILDELVQRGHEVTVLRPSSSVFLDPKK 68

  Fly    54 -SG-----FPADFNIEGLLEVTPAGLVEYIHNYTNWDLLGSRMAGEMPIKPWDGLRYA------- 105
             ||     ||...|.:.:.:.    ..::::.:| :|           :..:..|||.
  Rat    69 ASGLVYETFPTTSNNDEVEKF----FTQWVNTWT-YD-----------VPKYTCLRYYPSLNKMF 117

  Fly   106 -------FESCDAMLRDSETKELTKKS-FDLAILDGAFPECFLGLMYDFKIPFMYINTVGF-YTG 161
                   .:.|..::.:.......|:| ||:.:.|...| |...:....::||:|....|. |..
  Rat   118 GQFSDLWLQLCREVVSNKHLMAKLKESQFDVVLSDAVGP-CGELIAEILQLPFVYSLRFGIGYGI 181

  Fly   162 SISTAGNPVSYAITPNFYSRFTDTMNLYERAINTAMQIGQTLMHM------YVMRRTHLVMREHL 220
            ...:||.|...:..|...|..:..|...||..|..     .|::.      :..:.......|.|
  Rat   182 EKYSAGQPFPPSYVPIILSGLSGQMTFMERVENML-----CLLYFDFWFESFPAKDWDPFFSEIL 241

  Fly   221 GTQIPHPYEMSRNVSFILQNGHAVLSYPRAFNPNVAEVACIHCRPARKLPRNLEEFIGASGASGF 285
            |........|.:...::::: :..|.:||...||:..|..:||:||:.||:.:|:|..:||..|.
  Rat   242 GRPTTMVDTMKKAEIWLIRS-YWDLEFPRPSLPNIEFVGGLHCQPAKPLPKEMEDFAQSSGEHGV 305

  Fly   286 IYVSMGSSVKAANMPEALRHMLVKTFARLPYHVLWKYEGSSTDIKDITSNVKLSRWLPQQDILGH 350
            :..|:||.::  |:.:...:.:....|::|..|.|::||...|  .:..|.::.:|:||.|:|||
  Rat   306 VVFSLGSMIR--NITQERANTIASALAQIPQKVFWRFEGKKPD--TLGPNTRVFKWIPQNDLLGH 366

  Fly   351 PKLRAFVTHGGLLSMFETVYHGVPVVTMPVFCDHDVNSAKAEVDGYAIKLDLQTLSANQLYKAIM 415
            ||.:|||||||...::|:::||:|:|.:|:|.:...|.|.....|.|:.||..|:|::.|..|:.
  Rat   367 PKTKAFVTHGGANGIYESIHHGIPMVGIPLFAEQRDNVAHMVAKGAAVSLDFHTMSSSDLLNALK 431

  Fly   416 KVIHNPRYRNSARHRQKLFLDQRSTALDTAIYWTEYVLRHNGAYHLQTPSRNMTWWQYYLLDVVA 480
            .||:.|.|:........:..||....||.|::|.|:|:||.||.||:..:.|:.|:||:.|||:.
  Rat   432 AVINKPSYKKKVMWLSAIHHDQPLKPLDRAVFWIEFVMRHKGAKHLRPLAHNLAWYQYHSLDVIG 496

  Fly   481 VYL-ILLYVLILALRRIDFPYEKVRSLYSLMAPFITIAKTK 520
            ..| .:|.:::||::...|.|..          |:.:||.|
  Rat   497 FLLACVLAIVLLAVKCCLFLYRF----------FVKVAKNK 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt50B3	NP_001260710.1	YjiC	28..434	CDD:224732	113/456 (25%)
Ugt50B3	NP_001260710.1	egt	<172..479	CDD:223071	97/312 (31%)
Ugt2b7	NP_775445.2	UDPGT	24..527	CDD:278624	142/539 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm44525
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.810