DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt50B3 and Ugt2b17

DIOPT Version :9

Sequence 1:	NP_001260710.1	Gene:	Ugt50B3 / 246614	FlyBaseID:	FBgn0050438	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_775417.1	Gene:	Ugt2b17 / 286954	RGDID:	708541	Length:	529	Species:	Rattus norvegicus

Alignment Length:	549	Identity:	154/549 - (28%)
Similarity:	249/549 - (45%)	Gaps:	95/549 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LKKIALFLII--------WSCGTLAADILMATQGGTKSHKIPFWELAKGLISRGHNITFLSGFPA 58
            :|:.::||:|        .:||.:   ::..|:   .||.|....:...|..|||.:|.|..
  Rat     3 MKQTSVFLLIQLICYFRPGACGKV---LVWPTE---YSHWINIKIILNELAQRGHEVTVLVS--- 58

  Fly    59 DFNIEGLLEVTPAGLVEYIHNYTNWDLLGSRMAGEMPIKPWDGLRYAFES-CDAMLRDSET---- 118
              :...|:|.|....:       |:::.      .:|:...| |.|:|.. .|...||.||
  Rat    59 --SASILIEPTKESSI-------NFEIY------SVPLSKSD-LEYSFAKWIDEWTRDFETLSIW 107

  Fly   119 ---------------------------KELTKK----SFDLAILDGAFPECFLGLMYDFKIPFMY 152
                                       |.|.||    .||:.:.|...| |...|....|.|.:|
  Rat   108 TYYSKMQKVFNEYSDVVENLCKALIWNKSLMKKLQGSQFDVILADAVGP-CGELLAELLKTPLVY 171

  Fly   153 INTVGF---YTGSISTAGNPVSYAITPNFYSRFTDTMNLYERAINTAMQIGQTLMHMYVMRRTHL 214
              ::.|   |.....:.|.|:..:..|...|..:|.|...||..|        ::.|........
  Rat   172 --SLRFCPGYRCEKFSGGLPLPPSYVPVVLSELSDRMTFVERVKN--------MLQMLYFDFWFQ 226

  Fly   215 VMREHLGTQ-----IPHP---YEMSRNVSFILQNGHAVLSYPRAFNPNVAEVACIHCRPARKLPR 271
            ..:|...:|     :..|   .||.......|......|.:|..|.||...|..:||:||:.|||
  Rat   227 PFKEKSWSQFYSDVLGRPTTLTEMMGKADIWLIRTFWDLEFPHPFLPNFDFVGGLHCKPAKPLPR 291

  Fly   272 NLEEFIGASGASGFIYVSMGSSVKAANMPEALRHMLVKTFARLPYHVLWKYEGSSTDIKDITSNV 336
            .:|||:.:||..|.:..|:||.||  |:.|...:::....|::|..|:|:::|...|  .:.||.
  Rat   292 EMEEFVQSSGEHGVVVFSLGSMVK--NLTEEKANVVASALAQIPQKVVWRFDGKKPD--TLGSNT 352

  Fly   337 KLSRWLPQQDILGHPKLRAFVTHGGLLSMFETVYHGVPVVTMPVFCDHDVNSAKAEVDGYAIKLD 401
            :|.:|:||.|:|||||.:|||.|||...::|.:|||:|:|.:|:|.|...|.......|.|:::|
  Rat   353 RLYKWIPQNDLLGHPKTKAFVAHGGTNGIYEAIYHGIPIVGIPLFADQPDNINHMVAKGAAVRVD 417

  Fly   402 LQTLSANQLYKAIMKVIHNPRYRNSARHRQKLFLDQRSTALDTAIYWTEYVLRHNGAYHLQTPSR 466
            ...||...|..|:..|:::|.|:.:|....::..||....||.|::|.|||:||.||.||::...
  Rat   418 FSILSTTGLLTALKIVMNDPSYKENAMRLSRIHHDQPVKPLDRAVFWIEYVMRHKGAKHLRSTLH 482

  Fly   467 NMTWWQYYLLDVVAVYLILLYVLILALRR 495
            :::|:||:.|||:...|:.:..::..:.:
  Rat   483 DLSWFQYHSLDVIGFLLLCVVGVVFIITK 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt50B3	NP_001260710.1	YjiC	28..434	CDD:224732	125/452 (28%)
Ugt50B3	NP_001260710.1	egt	<172..479	CDD:223071	105/314 (33%)
Ugt2b17	NP_775417.1	UDPGT	24..527	CDD:278624	149/528 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm44525
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.810