DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt50B3 and Ugt2b15

DIOPT Version :9

Sequence 1:	NP_001260710.1	Gene:	Ugt50B3 / 246614	FlyBaseID:	FBgn0050438	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_695226.3	Gene:	Ugt2b15 / 266685	RGDID:	628623	Length:	530	Species:	Rattus norvegicus

Alignment Length:	531	Identity:	148/531 - (27%)
Similarity:	247/531 - (46%)	Gaps:	60/531 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 WSCGTLAADILMATQGGT----------KSHKIPFWELAKGLISRGHNITFLSGFPADFNI---- 62
            |....|...|....|.|.          .||.:....:...|:.|||.:|.|.  |:.:.:
  Rat     5 WISALLLLQISCCFQSGNCGKVLVWPMEFSHWMNIKTILDELVQRGHEVTVLK--PSAYYVLDPK 67

  Fly    63 ---EGLLEVTPAGL-VEYIHNY-------TNWDLLGSRMAGEMPI--KPWDGLR-YAFESC-DAM 112
               :...|..|..: .:.:.||       ..::|.........|:  ...||.. |....| |.:
  Rat    68 KSPDLKFETFPTSVSKDELENYFIKLVDVWTYELQRDTCLSYSPLLQNMIDGFSDYYLSLCKDTV 132

  Fly   113 LRDSETKELTKKSFDLAILD--GAFPECFLGLMYDFKIPFMYINTVGFYTG-SISTAGN----PV 170
            .......:|.:..||:.:.|  .|..|....:::   |||:|  ::.|..| .|..:..    |.
  Rat   133 SNKQLMAKLQESKFDVLLSDPVAACGELIAEVLH---IPFLY--SLRFSPGYKIEKSSGRFILPP 192

  Fly   171 SYAITPNFYSRFTDTMNLYERAINTAMQIGQTL-----MHMYVMRRTHLVMREHLGTQIPHPYEM 230
            ||  .|...|.....|...:|..|...    ||     .||:..::......|.||........|
  Rat   193 SY--VPVILSGMGGPMTFIDRVKNMIC----TLYFDFWFHMFNAKKWDPFYSEILGRPTTLAETM 251

  Fly   231 SRNVSFILQNGHAVLSYPRAFNPNVAEVACIHCRPARKLPRNLEEFIGASGASGFIYVSMGSSVK 295
            .:...::::: :..|.:|....|||..:..:.|||.:.||:::|:|:.:||..|.:..|:||.|
  Rat   252 GKAEMWLIRS-YWDLEFPHPTLPNVDYIGGLQCRPPKPLPKDMEDFVQSSGEHGVVVFSLGSMV- 314

  Fly   296 AANMPEALRHMLVKTFARLPYHVLWKYEGSSTDIKDITSNVKLSRWLPQQDILGHPKLRAFVTHG 360
             ::|.|...:.:....|::|..||||::|.:.  ..:..|.::.:||||.|:|||||.:||||||
  Rat   315 -SSMTEEKANAIAWALAQIPQKVLWKFDGKTP--ATLGPNTRVYKWLPQNDLLGHPKTKAFVTHG 376

  Fly   361 GLLSMFETVYHGVPVVTMPVFCDHDVNSAKAEVDGYAIKLDLQTLSANQLYKAIMKVIHNPRYRN 425
            |...::|.:|||:|:|.:|:|.:...|.|.....|.|:.|:::|:|.:.|:.|:.::|:||.|:.
  Rat   377 GANGVYEAIYHGIPMVGIPMFGEQHDNIAHMVAKGAAVTLNIRTMSKSDLFNALKEIINNPFYKK 441

  Fly   426 SARHRQKLFLDQRSTALDTAIYWTEYVLRHNGAYHLQTPSRNMTWWQYYLLDVVAVYLILLYVL- 489
            :|.....:..||....||.|::|.|:|:||.||.||:....|:.|:||:.|||:...|....|:
  Rat   442 NAVWLSTIHHDQPMKPLDKAVFWIEFVMRHKGAKHLRPLGHNLPWYQYHSLDVIGFLLTCSAVIA 506

  Fly   490 ILALRRIDFPY 500
            :|.::...|.|
  Rat   507 VLTVKSFLFIY 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt50B3	NP_001260710.1	YjiC	28..434	CDD:224732	118/446 (26%)
Ugt50B3	NP_001260710.1	egt	<172..479	CDD:223071	102/311 (33%)
Ugt2b15	NP_695226.3	UDPGT	24..527	CDD:278624	143/512 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm44525
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.810