DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt50B3 and Ugt2b35

DIOPT Version :9

Sequence 1:	NP_001260710.1	Gene:	Ugt50B3 / 246614	FlyBaseID:	FBgn0050438	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_766469.1	Gene:	Ugt2b35 / 243085	MGIID:	3576100	Length:	529	Species:	Mus musculus

Alignment Length:	579	Identity:	156/579 - (26%)
Similarity:	251/579 - (43%)	Gaps:	120/579 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ALFLIIWSCGTLAADILMATQGGTKSHKIPFWEL-----------AKGLISRGHNITFL------ 53
            ||.|:..||      ...:|..|    |:..|.|           ...|:.|||.:|.|
Mouse     8 ALLLLQMSC------CFRSTSCG----KVLVWPLEFSHWMNLKIILDELVQRGHEVTVLRPSASI 62

  Fly    54 ------------SGFPADFNIEGLLEVTPAGLVEYIHNYT---------NWDLLGSRMAGEMPIK 97
                        ..||..|: :..||..   |.:.:..:|         ::.|| ..:.|::.
Mouse    63 FVDPKYSPGLKFETFPTAFS-KDYLETF---LTKLVDEWTFEVPRDTCLSYSLL-QTLFGKLS-- 120

  Fly    98 PWDGLRYAFESC-DAMLRDSETKELTKKSFDLAILDGAFPECFLGLMYDFKIPFMYI-------- 153
                 .|:...| :|:.......:..:..||:.||| |...|...:....:|||:|.
Mouse   121 -----DYSLSLCKEAVSNKQLMTKFQESKFDVLILD-AMASCGELIAQLLQIPFLYSLRFSPGYQ 179

  Fly   154 ---NTVGFYTGSISTAGNPVSYAITPNFYSRFTDTMNLYERAIN-TAMQIGQTLMHMYVMRRTHL 214
               |:.||..        |.||  .|...|.....|...||..| ..|.........:..:....
Mouse   180 VEKNSGGFVL--------PPSY--VPVILSGLGGQMTFTERVKNMICMLYFDFWFQTFTEKEWDQ 234

  Fly   215 VMREHLGTQIPHPYEMSRNVSFILQNGHAV---------LSYPRAFNPNVAEVACIHCRPARKLP 270
            ...|.||          |..:.|...|.|.         |.:|....|||..|..:||:||:.||
Mouse   235 FYSETLG----------RPTTLIETMGKAEMWFIRSYWDLEFPHPTLPNVEYVGGLHCKPAKPLP 289

  Fly   271 RNLEEFIGASGASGFIYVSMGSSVKAANMPEALRHMLVKTFARLPYHVLWKYEGSSTDIKDITSN 335
            :.:|:|:.:||..|.:..|:||.|  :||.|...:.:....|::|..|||:::|.:.  ..:..|
Mouse   290 KEMEDFVQSSGVHGVVVFSLGSMV--SNMTEERANAISWALAQIPQKVLWRFDGKTP--ASLGPN 350

  Fly   336 VKLSRWLPQQDILGHPKLRAFVTHGGLLSMFETVYHGVPVVTMPVFCDHDVNSAKAEVDGYAIKL 400
            .::.:||||.|:|||||.:|||||||...::|.::||:|::.:|:|.:...|.|.....|.|:.|
Mouse   351 TRIYKWLPQNDLLGHPKTKAFVTHGGANGLYEAIHHGIPMIGIPLFSEQHDNIAHMVAKGTAVAL 415

  Fly   401 DLQTLSANQLYKAIMKVIHNPRYRNSARHRQKLFLDQRSTALDTAIYWTEYVLRHNGAYHLQTPS 465
            :::|:|.:.|..|:.:||:||.|:.:......:..||....|:..|:|.|:|:||.||.||:..:
Mouse   416 NIRTMSRSDLLNALEEVINNPSYKENVMWLSTIHHDQPMKPLNRTIFWIEFVMRHKGAKHLRPLA 480

  Fly   466 RNMTWWQYYLLDVVAVYLI-LLYVLILALRRIDFPYEKVRSLYSLMAPFITIAKTKSKK 523
            .|:||:||:.|||:...|: ::...:|.::...|.|:            ..:.|.|.:|
Mouse   481 HNLTWYQYHSLDVIGFLLVCVVATAVLPVKCCLFVYQ------------FFVKKAKKRK 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt50B3	NP_001260710.1	YjiC	28..434	CDD:224732	122/465 (26%)
Ugt50B3	NP_001260710.1	egt	<172..479	CDD:223071	103/316 (33%)
Ugt2b35	NP_766469.1	egt	8..506	CDD:223071	150/544 (28%)
Ugt2b35	NP_766469.1	UDPGT	24..525	CDD:278624	148/553 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.810