DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt50B3 and Ugt8a

DIOPT Version :9

Sequence 1:	NP_001260710.1	Gene:	Ugt50B3 / 246614	FlyBaseID:	FBgn0050438	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_035804.2	Gene:	Ugt8a / 22239	MGIID:	109522	Length:	541	Species:	Mus musculus

Alignment Length:	524	Identity:	170/524 - (32%)
Similarity:	273/524 - (52%)	Gaps:	46/524 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 FLIIWSCGTL--AADILMATQGGTKSHKIPFWELAKGLISRGHNITFLSGFPADFNIEGLLEVTP 70
            |:::||...:  ||.|::......:||...|..||..|..|||:...|..       || .::.|
Mouse     8 FMLLWSAVGIARAAKIIIVPPIMFESHLYIFKTLASALHERGHHTVLLLS-------EG-RDIAP 64

  Fly    71 A---GLVEY--IHNYTNWD-LLGSRM----AGEM-PIKPWDGLRYAFESCDAML-RDSETKELTK 123
            :   .|..|  |.|.|..| .|.|:|    :|.: .::..|.|.:..::||.|: ..:..:.|.|
Mouse    65 SNHYSLQRYPGIFNSTTSDAFLQSKMRNIFSGRLTAVELVDILDHYTKNCDMMVGNQALIQGLKK 129

  Fly   124 KSFDLAILDGAFPE--CFLGLMYDFKIPFMYINTVGFYTGSISTAGNPVSYAITPNFYSRFTDTM 186
            :.|||.::|   |.  |...:.:...:.:...:|..:|...:   |.|...|..|.|.|..||.|
Mouse   130 EKFDLLLVD---PNDMCGFVIAHLLGVKYAVFSTGLWYPAEV---GAPAPLAYVPEFNSLLTDRM 188

  Fly   187 NLYERAINTAM----QIGQTLMHMYVMRRTHLVMREHLGTQIPHPYEMSRNVSFILQNGHAVLSY 247
            |..||..||.:    :||.:.:   |:.:...:|:::........|::....|..:......|.:
Mouse   189 NFLERMKNTGVYLISRIGVSFL---VLPKYERIMQKYNLLPAKSMYDLVHGSSLWMLCTDVALEF 250

  Fly   248 PRAFNPNVAEVACIHCRPARKLPRNLEEFIGASGASGFIYVSMGSSVKAANMPEALRHMLVKTFA 312
            ||...|||..|..|..:||..||.:|:.::..:...||:.||.|:.||  .:.|.:.:.|.....
Mouse   251 PRPTLPNVVYVGGILTKPASPLPEDLQRWVSGAQEHGFVLVSFGAGVK--YLSEDIANKLAGALG 313

  Fly   313 RLPYHVLWKYEGSSTDIKDITSNVKLSRWLPQQDILGHPKLRAFVTHGGLLSMFETVYHGVPVVT 377
            |||..|:|::.|  |..|::.:|.||..||||.|:|||..:|||::||||.|:|||:|||||||.
Mouse   314 RLPQKVIWRFSG--TKPKNLGNNTKLIEWLPQNDLLGHSNIRAFLSHGGLNSIFETMYHGVPVVG 376

  Fly   378 MPVFCDHDVNSAKAEVDGYAIKLDLQTLSANQLYKAIMKVIHNPRYRNSARHRQKLFLDQRSTAL 442
            :|:|.||.....:.:..|..|.|:..|::..:||.|::|||:||.||..|:...::..||....:
Mouse   377 IPLFGDHYDTMTRVQAKGMGILLEWNTVTEGELYDALVKVINNPSYRQRAQKLSEIHKDQPGHPV 441

  Fly   443 DTAIYWTEYVLRHNGAYHLQTPSRNMTWWQYYLLDVVAVYL---ILLYVLILALRRIDFPYEKVR 504
            :...||.:|:|||:||.||::....:::.||:|||:..|.|   :|||.::..:.:  |.|.|::
Mouse   442 NRTTYWIDYILRHDGARHLRSAVHQISFCQYFLLDIAFVLLLGAVLLYFILSYVTK--FIYRKIK 504

  Fly   505 SLYS 508
            ||:|
Mouse   505 SLWS 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt50B3	NP_001260710.1	YjiC	28..434	CDD:224732	136/423 (32%)
Ugt50B3	NP_001260710.1	egt	<172..479	CDD:223071	113/310 (36%)
Ugt8a	NP_035804.2	UDPGT	21..502	CDD:278624	162/503 (32%)
Ugt8a	NP_035804.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	518..541
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20715
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.678979	Normalized mean entropy	S5661
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2881
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.790