DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt50B3 and Ugt1a2

DIOPT Version :9

Sequence 1:	NP_001260710.1	Gene:	Ugt50B3 / 246614	FlyBaseID:	FBgn0050438	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_038729.1	Gene:	Ugt1a2 / 22236	MGIID:	3576049	Length:	533	Species:	Mus musculus

Alignment Length:	531	Identity:	153/531 - (28%)
Similarity:	250/531 - (47%)	Gaps:	80/531 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 IALFLIIWSCGTLAADILMATQGGTKSHKIPFW----ELAKGLISRGHNITFLSGFPADFNIEGL 65
            :.|..:.|:.|   |.:|:....|::      |    ::.:.|.:|||....|:. ....:|:|.
Mouse    17 LLLCALPWAEG---AKVLVLPMEGSQ------WLSMRDVVRELHARGHQTVVLAS-EVTVHIKGE 71

  Fly    66 LEVTPAGLVEYIHNYTNWDLLGSRMAG-EMPIKPWDGLRYAFE--------------SCDAMLRD 115
            ...|   |..|...||..:.....::. |...|....::..||              ||.|:|.:
Mouse    72 DFFT---LKTYAFPYTKEEYQQEILSDIEKTFKTQHFVKAFFETTASIRNFFDLYSNSCIALLHN 133

  Fly   116 SE-TKELTKKSFDLAILDGAFPECFLGLMYDFKIPFMYINTVGFYTGSIS--------TAGNPVS 171
            .. .::|....||:.:.|..|| |...|....:||.::|      ..|:|        ...||.|
Mouse   134 KMLIQQLNSSFFDVILTDPIFP-CGAVLAKYLQIPAVFI------LRSLSCGIEYEATQCPNPSS 191

  Fly   172 YAITPNFYSRFTDTMNLYERAINTAMQIGQTLMHMYVMR---RTHLVMREHLGTQIPHPYEMSRN 233
            |  .||..:|.:|.|:..:|.        |.:::..|::   |..:...|.|.:::     :.|.
Mouse   192 Y--IPNLLTRLSDHMDFLQRV--------QNMLYYLVLKYICRLSITPYESLASEL-----LQRE 241

  Fly   234 VSFI---------LQNGHAVLSYPRAFNPNVAEVACIHCRPARKLPRNLEEFIGASGASGFIYVS 289
            ||.:         |..|..||.|||...||:..:..|:|...:.|.:..|.::.|||..|.:..|
Mouse   242 VSLVEVLSHASVWLFRGDFVLDYPRPIMPNMVFIGGINCVTKKPLSQEFEAYVNASGEHGIVVFS 306

  Fly   290 MGSSVKAANMPEALRHMLVKTFARLPYHVLWKYEGSSTDIKDITSNVKLSRWLPQQDILGHPKLR 354
            :||.|  :.:||.....:.:...|:|..|||:|.|  |...::..|..|.:||||.|:|||||.|
Mouse   307 LGSMV--SEIPEKKAMEIAEALGRIPQTVLWRYTG--TRPSNLAKNTILVKWLPQNDLLGHPKTR 367

  Fly   355 AFVTHGGLLSMFETVYHGVPVVTMPVFCDHDVNSAKAEVDGYAIKLDLQTLSANQLYKAIMKVIH 419
            ||:||.|...::|.:.:|||:|.||:|.|...|:.:.|..|..:.|::..::|:.|..|:..||:
Mouse   368 AFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVIN 432

  Fly   420 NPRYRNSARHRQKLFLDQRSTALDTAIYWTEYVLRHNGAYHLQTPSRNMTWWQYYLLDVVAVYL- 483
            |..|:.:......|..|:....||.|::|.|||:||.||.||:..:.::||:||:.|||:...|
Mouse   433 NKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLA 497

  Fly   484 ILLYVLILALR 494
            |:|.|:.:..:
Mouse   498 IVLTVVFIVFK 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt50B3	NP_001260710.1	YjiC	28..434	CDD:224732	122/445 (27%)
Ugt50B3	NP_001260710.1	egt	<172..479	CDD:223071	105/318 (33%)
Ugt1a2	NP_038729.1	UDPGT	28..524	CDD:278624	150/517 (29%)
		Glycosyltransferase_GTB_type	43..>175	CDD:299143	31/142 (22%)
		egt	<261..505	CDD:223071	93/247 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.810