DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt50B3 and ugt-31

DIOPT Version :9

Sequence 1:	NP_001260710.1	Gene:	Ugt50B3 / 246614	FlyBaseID:	FBgn0050438	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_001021756.1	Gene:	ugt-31 / 189771	WormBaseID:	WBGene00021464	Length:	521	Species:	Caenorhabditis elegans

Alignment Length:	541	Identity:	129/541 - (23%)
Similarity:	227/541 - (41%)	Gaps:	56/541 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 KIALFLIIWSCGTLAADILMATQ--GGTKSHKIPFWELAKGLISRGHNITFLSGFPADF--NIEG 64
            |..:|..|....:...:||:.:.  ||  ||......:|..|...|||:|||... ||.  ..|.
Worm     2 KFFIFFPILLVASEPLNILVYSPVFGG--SHSKFMGNIADTLTEAGHNVTFLVSV-ADVTRRHEI 63

  Fly    65 LLEVTPAGLVEYIHNYTNWDLLGSRMAGEMPIKP-W------DGLRYAFE--------SCDAMLR 114
            .:::|...::....|::..|:   .:..:..::| |      ......||        :|.....
Worm    64 GVKLTKNVIIVDKPNFSQDDV---EIDMDEVLRPLWTIQNRPSDFATCFEFFIQMMQTTCAEFTS 125

  Fly   115 DSET-KELTKKSFDLAILDGAFPECFLGLMY----DFKIPFMYINTVGFYTGSISTAGNPVSYAI 174
            :.|. |:|:|..|.:||   |.|....||.|    ..|...:..:|. .|.|.:..:|.||..:.
Worm   126 NREIFKKLSKTEFHVAI---AEPVSICGLGYFDALGIKKTILASSTT-HYEGVVRNSGEPVDMSY 186

  Fly   175 TPNFYSRFTDTMNLYERAINTAMQ--IGQTLMHMYVMRRTHLVMREHLGTQIPHPYEMSRNVSFI 237
            .|...:.|.:.|::::|..|.|.:  :...|..|:....:.  .|::|.....|..::..:.|.:
Worm   187 VPVHGAYFDEKMDIFQRYTNWASEHVLAGNLERMFDQEMSE--YRKNLVQSTGHWRDLIPSASLM 249

  Fly   238 LQNGHAVLSYPRAFNPNVAEVACIHCR----PARKLPRNLEEFIGASGASGFIYVSMGSSVKAAN 298
            ..|.:..|.:||........:..|...    .:.|||..:.:.:.....:  :.:|.||.||::.
Worm   250 FTNSNPYLDFPRPVLQKTVGIGGITVDMEQIKSEKLPEKINKLLEKREYN--MLISFGSMVKSST 312

  Fly   299 MPEALRHMLVKTFARLP-YHVLWKYEGSSTDIKDITSNVKLSRWLPQQDILGHPKLRAFVTHGGL 362
            |||..|:.::......| ...:||||.......:...||...:|:||..:|.:|::.||:|||||
Worm   313 MPEKWRNSILSAIRNFPNVTFIWKYESDDLRWAENVENVHFLKWIPQTALLNNPRVSAFLTHGGL 377

  Fly   363 LSMFETVYHGVPVVTMPVFCDHDVNSAKAEVDGYAI---KLDLQTLSANQLYKAIMKVIHNPRYR 424
            .|..|..:.|.|.:.:|:|.|...|:......|.|:   |.||:  :|..|...|.|::.:..|.
Worm   378 GSTNELAFIGKPSIIVPIFGDQGRNAPMLARHGGALVLQKFDLE--NAEVLIDFIGKIVFDKSYA 440

  Fly   425 NSARHRQKLFLDQRSTALDTAIYWTEYVLRHNGAYHLQTPSRNMTWWQYYLLDVVAVYLILLYVL 489
            .:|:....|......:..:..:..||:|........:....|.:.|:|....|:..: |.|:|..
Worm   441 KNAKTLANLLNASPFSPKELVVKNTEFVGNFGPLTQMDPYIRKLNWFQRTFADIYLI-LFLVYAS 504

  Fly   490 ILALRRIDFPYEKVRSLYSLM 510
            |:.:     |...:|.::.|:
Worm   505 IIVI-----PIYVIRKVFRLI 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt50B3	NP_001260710.1	YjiC	28..434	CDD:224732	108/437 (25%)
Ugt50B3	NP_001260710.1	egt	<172..479	CDD:223071	75/316 (24%)
ugt-31	NP_001021756.1	UDPGT	28..518	CDD:278624	122/511 (24%)
ugt-31	NP_001021756.1	Glycosyltransferase_GTB_type	<248..472	CDD:299143	59/227 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	172	1.000	Inparanoid score	I2735
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45374
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.870