DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt50B3 and ugt-54

DIOPT Version :9

Sequence 1:	NP_001260710.1	Gene:	Ugt50B3 / 246614	FlyBaseID:	FBgn0050438	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_501996.2	Gene:	ugt-54 / 188885	WormBaseID:	WBGene00012013	Length:	527	Species:	Caenorhabditis elegans

Alignment Length:	555	Identity:	138/555 - (24%)
Similarity:	239/555 - (43%)	Gaps:	85/555 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LKKIALFLII---WSCGTLAADILMATQGGTKSHKIPFWELA-KGLISRGHNITFLSGFPADFNI 62
            :|.:..|||:   .:|    .:||.......:|| |||...| |.|:.|||.:        |..|
Worm     1 MKTLLGFLILPGFANC----LNILFYVSVIAQSH-IPFHNTAIKVLLDRGHTV--------DLVI 52

  Fly    63 EGLLEVT----PAGLVEYIHNYTNWDLLG-------SRMAG-------EMPIKPWDGLRY---AF 106
            ..|.|:.    |.|:.:   |||    .|       .:.||       |.||...:.|.:   .|
Worm    53 AQLNEMVKLKFPNGVGK---NYT----FGYEDPNFYRKNAGHLSDIFVEKPIPMAEFLTFDDMTF 110

  Fly   107 ESCDAMLRDSETKELTKK-SFDLAILDGAFPECFLGLMYDFKIPF-MYINTVGFYTGSISTAGNP 169
            ..|:.:::|.......|: ::|:. |...:..|...||:...:|. ..:.....:...|.:||.|
Worm   111 NLCETVVKDPNLLNYIKQGNYDIG-LSSDYDPCANILMHAGGVPSKASMVPTPLFQPQIVSAGLP 174

  Fly   170 VSYAI---------TPNFYSR----FTDTMNLYERAINTAMQIGQTLMHMYVMRRTHLVMREHLG 221
            ...::         ..:|::|    ...|.|:|        .:...||..|     :.::.|..|
Worm   175 SPASVYGTVLYPKGDDSFFNRLFHLIRHTYNIY--------FVAPRLMEKY-----NNLLLETFG 226

  Fly   222 TQIPHPYEMSRNVSFILQNGHAVLSYPRAFNPNVAEVACIHCRPARKLPRNLEEFIGASGASGFI 286
            ...|...|:.|||..||.|.:.::..||..:..:..:..:..:.|:.|.:...:.:..|. .|.:
Worm   227 PTFPSAEEIERNVDIILVNSNEIIEKPRPVSHKIKYIGGMGKKKAQPLNKEFNDILATSN-KGVV 290

  Fly   287 YVSMGSSVKAANMPEALRHMLVKTFARLP-YHVLWKYEGSSTDIKDI--TSNVKLSRWLPQQDIL 348
            ..|.|:.|..:.:|..:|...|..|...| :..||||:..:.|.:..  :||:....||||.|:|
Worm   291 LFSFGTQVATSKVPIEIRKNFVTAFKHFPDFSFLWKYDNLTDDAELFADSSNIHRVEWLPQTDLL 355

  Fly   349 GHPKLRAFVTHGGLLSMFETVYHGVPVVTMPVFCDHDVNSAKAEVDGYAIKLDLQTLSANQLYKA 413
            |..:::||::|.||.|..||...|:||:.:|:|.|...|:..|......:.::...|:...|..|
Worm   356 GDNRVKAFISHMGLNSFLETSAAGIPVLAVPLFIDQQHNALNAVSRDIGVIVERHQLTVENLVNA 420

  Fly   414 IMKVIHNPRYRNSARHRQKLFLDQRSTALDTAIYWTEYVLRHNGAYHLQT-PSRNMTWWQYYLLD 477
            :.|:::||:|..:|:...|:..::...:....:.|.||..::.|.:.:.. |...:|.:.||.:|
Worm   421 LQKLLYNPKYGENAKMISKMMNEKPEQSERLFVDWVEYAAKNPGLHKIMNLPGAELTPFWYYSVD 485

  Fly   478 VV-AVYLILLYVLILALRRIDF-----PYEKVRSL 506
            |: .|.|.|...||:..:.:.|     ....|||:
Worm   486 VILIVVLSLTSSLIIIWKTLSFIKCQISIRSVRSI 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt50B3	NP_001260710.1	YjiC	28..434	CDD:224732	112/445 (25%)
Ugt50B3	NP_001260710.1	egt	<172..479	CDD:223071	80/323 (25%)
ugt-54	NP_501996.2	UDPGT	35..507	CDD:278624	122/501 (24%)
ugt-54	NP_501996.2	egt	<218..498	CDD:223071	76/280 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.810