DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt50B3 and ugt-20

DIOPT Version :9

Sequence 1:	NP_001260710.1	Gene:	Ugt50B3 / 246614	FlyBaseID:	FBgn0050438	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_500913.1	Gene:	ugt-20 / 187130	WormBaseID:	WBGene00019516	Length:	529	Species:	Caenorhabditis elegans

Alignment Length:	527	Identity:	130/527 - (24%)
Similarity:	220/527 - (41%)	Gaps:	46/527 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LFLIIWS-CGTLAADILMATQGGTKSHKIPFWELAKGLISRGHNITFLSGFPA-DFNIEGLLEVT 69
            |||:..: |...:..||..|.....||.......|..|...|||:|.|  .|. |..::..|:.|
Worm     4 LFLLFSAICFASSYKILFYTNLFGHSHVKFLGAAADTLTDAGHNVTVL--IPVFDKALKTSLKST 66

  Fly    70 PAGLV----EYIHNYTN---------WDLLGSRMAGEMPIKPWDGLRYAFES-CDAMLRDSE-TK 119
            ...::    |.|.|:..         |  |.........||..:.:...|.| |..:|.::: .:
Worm    67 KNVIMLQPTEDIANFVKGRATMLKNIW--LQDNTNPLTMIKKVETMSKIFSSQCKRVLSETDIIE 129

  Fly   120 ELTKKSFDLAILDGAFPECFLGLMYDFKIPFMYINT--------VGFYTGSISTAGNPVSYAITP 176
            :|..:::||||.: .|..|    .|:|   |..|.|        ...|.......|.|.:.:..|
Worm   130 KLKAENYDLAITE-PFDTC----AYEF---FEAIETRTHVAILSASRYDHVSDVIGQPAAASYNP 186

  Fly   177 NFYSRFTDTMNLYERAINTAMQIGQTLMHMYVMRRTHLVMREHLGTQIPHPYEMSRNVSFILQNG 241
            ...|...|.|.:.:|.:|.......:....||..:...|.:| :..:.....|.....|||:.|.
Worm   187 GLLSSNGDQMTMPQRLLNLIQYAAGSYFFSYVGDKDAEVAKE-INPKWRSWRETLPEASFIMTNQ 250

  Fly   242 HAVLSYPRAFNPNVAEVACIHCRPAR---KLPRNLEEFIGASGASGFIYVSMGSSVKAANMPEAL 303
            ..:|.:|......:..:..:..:..:   ||.....:.:.....:  :::|.||:.::.:||...
Worm   251 IPLLDFPAPTFDKIIPIGGLSVKTDKKSLKLEEKWSKILDIRKKN--VFISFGSNARSVDMPLEY 313

  Fly   304 RHMLVKTFARLP-YHVLWKYEGSSTDIKDITSNVKLSRWLPQQDILGHPKLRAFVTHGGLLSMFE 367
            :...::....:| ...:||||..:....:...||.|..||||.::|...:|..|||||||.|:.|
Worm   314 KKTFLQVIKSMPDTTFIWKYEDLNDKFTEGIENVYLGDWLPQNELLADKRLNVFVTHGGLGSVTE 378

  Fly   368 TVYHGVPVVTMPVFCDHDVNSAKAEVDGYAIKLDLQTLSANQL-YKAIMKVIHNPRYRNSARHRQ 431
            ....|.|.|.:|:|.|...|:...:..|.|..|....||..:| .:.|.|||:|..||.:|....
Worm   379 LSMMGTPAVMIPLFADQSRNAQMLKRHGGAAVLVKNDLSNPKLVQETIEKVINNSEYRKNAERLS 443

  Fly   432 KLFLDQRSTALDTAIYWTEYVLRHNGAYHLQTPSRNMTWWQYYLLDVVAVY-LILLYVLILALRR 495
            ::..:..:...:|.:.:.|:..|......|....|..::.:|:.||::|:: ||.|..|.::.|.
Worm   444 EMLNNLPTNPRETLVKYVEFAARFGKLPSLDNYGRQQSFVEYFFLDIIAIFILITLIFLYVSFRI 508

  Fly   496 IDFPYEK 502
            :.|.:.|
Worm   509 VKFAFRK 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt50B3	NP_001260710.1	YjiC	28..434	CDD:224732	107/434 (25%)
Ugt50B3	NP_001260710.1	egt	<172..479	CDD:223071	76/311 (24%)
ugt-20	NP_500913.1	UDPGT	29..518	CDD:278624	123/502 (25%)
ugt-20	NP_500913.1	egt	<268..500	CDD:223071	62/233 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	161	1.000	Domainoid score	I2438
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	172	1.000	Inparanoid score	I2735
Isobase	1	0.950	-	0.678979	Normalized mean entropy	S5661
OMA	1	1.010	-	-		QHG45374
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.820