DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt50B3 and ugt-14

DIOPT Version :9

Sequence 1:	NP_001260710.1	Gene:	Ugt50B3 / 246614	FlyBaseID:	FBgn0050438	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_504316.1	Gene:	ugt-14 / 186767	WormBaseID:	WBGene00019233	Length:	531	Species:	Caenorhabditis elegans

Alignment Length:	546	Identity:	134/546 - (24%)
Similarity:	230/546 - (42%)	Gaps:	90/546 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LKKIALFLIIW---SCGTLAADILMATQGGTKSHKIPFWELAKGLISRGHNITFLSGFP-ADFNI 62
            :|.:..||:..   ||    .:||:.......||.....::|..:...|||:|....:. |..|.
Worm     3 VKTLVYFLLFTGFISC----KNILIFNPIFAFSHVKFVTQMADIIADHGHNVTLFQPYHIAMKNT 63

  Fly    63 EGLLEVTPAGLVEYI-HNYTNWDLLGSRMAGEMPIKPWDGL------------RYA--------F 106
            |||::.....::.|. |::       :.::|.|| :.:.||            .||        |
Worm    64 EGLVKNRKVNIINYYPHDF-------NTISGAMP-ETFSGLWDSKLLNNAILSAYAMPKAIGRVF 120

  Fly   107 ESCDAMLRDSET--KELTKKSFDLAILDGAFPECFLGLMYDFKIPFMYINTVGFYTGSISTAGNP 169
            |.....|...|:  :||..:.|::.|.: ||....:.|.:..|||.:.|.:...|....:..|.|
Worm   121 EKTATQLLQDESILEELKSRKFEVVISE-AFEITEMYLAHLLKIPSIPIKSSVRYPAFNNAFGQP 184

  Fly   170 VSYAITP--------NFYSRFTDTMNLYERAINTAMQIGQTLMHMYVMRRTHLVMREHLGTQIPH 226
            .|....|        .|..|.   :.:|:......|   |..::.|.:.    .:.:.||..:||
Worm   185 SSLGYLPQQGLSREIGFLDRL---LEVYDHYFLVKM---QERLNEYQVN----FIEKALGHPVPH 239

  Fly   227 PYEMSRNVSFILQNGHAVLSYPRAFNPNVAEVACI-----HCRPARKLPRNLEEFIGASGASGFI 286
            ..::.:.....:.|.:..|.:.......|..|..|     ..:..::||...||.:....::  :
Worm   240 WRDLVKESPIYITNSNPYLDFAVPTTATVVHVGGITMDMKKLKNPQQLPDEYEEILQERDST--V 302

  Fly   287 YVSMGSSVKAANMPEALRHMLVKTFARLP-YHVLWKYEGSSTDI-KDITSNVKLSRWLPQQDILG 349
            .:|.||.|::.:|||..:..:||.|..|| ...:||||....:. |.:..||.|.:|:||..:|.
Worm   303 LISFGSVVRSCDMPENFKAGVVKMFESLPDITFIWKYEKDDVEFQKKLPKNVHLKKWVPQPSLLA 367

  Fly   350 HPK-LRAFVTHGGLLSMFETVYHGVPVVTMPVFCDHDVNSAKAEVDGYAI---KLDLQTLSANQL 410
            ..: ::.|||||||.|..|..|.|.|.:.:|:|.|...|:......|.||   ||||  ....:.
Worm   368 DKRFVKRFVTHGGLGSTMEVAYTGKPALMVPIFADQFNNANMLARHGGAIPYDKLDL--ADGEKF 430

  Fly   411 YKAIMKVIHNPRYRNSARHRQKLFLDQRSTALDTAIYWTEYVLRHNGAYHLQTPS--------RN 467
            .|.:.:::.||:|.::|:....:.|:|   .:|..:...:::     .:.::.|:        .|
Worm   431 TKTVREMVINPKYNDNAKVLLIILLNQ---PIDPKLNLMKHL-----EFAMEFPNLRSQIPEINN 487

  Fly   468 MTWWQYYLLDVVAVYLILLYVLILAL 493
            .....||.||::| :.||...|.|.|
Worm   488 AGLIGYYYLDIIA-FFILFACLALYL 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt50B3	NP_001260710.1	YjiC	28..434	CDD:224732	112/448 (25%)
Ugt50B3	NP_001260710.1	egt	<172..479	CDD:223071	81/333 (24%)
ugt-14	NP_504316.1	egt	5..461	CDD:223071	120/485 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45374
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.820