DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt50B3 and ugt-15

DIOPT Version :9

Sequence 1:	NP_001260710.1	Gene:	Ugt50B3 / 246614	FlyBaseID:	FBgn0050438	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_506211.1	Gene:	ugt-15 / 183462	WormBaseID:	WBGene00008097	Length:	534	Species:	Caenorhabditis elegans

Alignment Length:	537	Identity:	125/537 - (23%)
Similarity:	218/537 - (40%)	Gaps:	108/537 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 SHKIPFWELAKGLISRGHNITFLSGFPADFNIEGLLEVTPAGLVEYIHNYTNWDLLGSRMAGEMP 95
            ||.....:::..||..||::|.|        |...:|             :..||:||:...::
Worm    30 SHSNFLGKISDILIDAGHDVTML--------IPVCME-------------SKKDLVGSKKVKKI- 72

  Fly    96 IKPWDGLRYAFESCDAMLR-DSETKELTK-----------------KSFDL-------------A 129
                  :|...|....::: :::|:|:.|                 |:|.:             |
Worm    73 ------IRIDQEPRSKLMQEEAKTEEMIKKQIWKLDADITIFFSMIKNFSIASGYQCENIFKQTA 131

  Fly   130 ILDGAFPECF-LGLMYD-FKIPFMYINTVG----------FYTGSISTA-GNPVSYAITPNFYSR 181
            ||:....|.| ||:... |...|..::::|          .|...:..| |.|.|.:..|..|::
Worm   132 ILEQLRNEHFDLGITESLFICGFPLLDSIGVKTIINADSVLYLDVVKHALGEPASTSYYPGVYAK 196

  Fly   182 FTDTMNLYERAINTAMQIGQTLMHMYVMRR-------------THLVMREHLGTQIPHPYEMSRN 233
            ..|.|:..||..|.   .|......:...|             ..|...:|:           ..
Worm   197 NIDRMSFRERVRNL---FGMAFSWYFSWTRFQGELEAIKPYYNKSLTWEDHI-----------NG 247

  Fly   234 VSFILQNGHAVLSYPRAFNPNVAEVACIHCRPAR----KLPRNLEEFIGASGASGFIYVSMGSSV 294
            .::...|.:..|.||....|....:..:.....:    ||.:..::.:.....:  :.||.||:.
Worm   248 AAYYFINSNQYLDYPSPTLPKTVFIGGMQVNTNKHGKVKLEKEWDDLLNLRKQN--VLVSFGSNA 310

  Fly   295 KAANMPEALRHMLVKTFARLPYHV-LWKYEGSSTDIKDITSNVKLSRWLPQQDILGHPKLRAFVT 358
            .:.:||:..:...:|.||.:|... :||||..:..:.|..|||||:.|:||.|||...:|..|||
Worm   311 FSCDMPDEFKESFLKVFASMPETTFIWKYEQENATLADQLSNVKLTTWMPQNDILADERLTLFVT 375

  Fly   359 HGGLLSMFETVYHGVPVVTMPVFCDHDVNSAKAEVDGYAIKLDLQTL-SANQLYKAIMKVIHNPR 422
            ||||.|..|..|.|.|.|.:|:..|...|:......|.|::||...| ::.::.:||..|:.||.
Worm   376 HGGLGSSMELAYQGKPAVVIPLMADQPRNALMLTRHGGALQLDKTFLNNSEKIREAIQTVMENPS 440

  Fly   423 YRNSARHRQKLFLDQRSTALDTAIYWTEYVLRHNGAYHLQTPSRNMTWWQYYLLDV-VAVYLILL 486
            |:.:|.....:...|.....|..:...::.::|.....|.:..|::..:|||.:|: :|..|.|:
Worm   441 YKKNAEKLANILSSQPHQPKDVVLKHCDFAVKHGDLKTLNSEGRHLNVFQYYSIDIALAAGLFLV 505

  Fly   487 YVLILALRRIDFPYEKV 503
            .::...:..|.|.::||
Worm   506 TIISFIIFTIIFVFKKV 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt50B3	NP_001260710.1	YjiC	28..434	CDD:224732	109/465 (23%)
Ugt50B3	NP_001260710.1	egt	<172..479	CDD:223071	82/326 (25%)
ugt-15	NP_506211.1	UDPGT	19..506	CDD:278624	121/519 (23%)
ugt-15	NP_506211.1	Glycosyltransferase_GTB_type	<252..493	CDD:299143	69/242 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	161	1.000	Domainoid score	I2438
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	172	1.000	Inparanoid score	I2735
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45374
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.870