DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt50B3 and ugt-23

DIOPT Version :9

Sequence 1:	NP_001260710.1	Gene:	Ugt50B3 / 246614	FlyBaseID:	FBgn0050438	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_001076755.1	Gene:	ugt-23 / 181205	WormBaseID:	WBGene00007650	Length:	530	Species:	Caenorhabditis elegans

Alignment Length:	506	Identity:	122/506 - (24%)
Similarity:	208/506 - (41%)	Gaps:	89/506 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 LISRGHNITFL---------------SG-----FPADFNIEGLLEVTPAGLVEYIHNYTNWDLLG 87
            |:..||::|.:               ||     ..||..:..:...|.    :::.|.  |.:
Worm    43 LVDAGHDVTVVLPVIDSTQKNRTSIKSGAKQIIIDADEEVVEIFSQTE----KFLSNM--WTM-- 99

  Fly    88 SRMAGEM--PIKPWDGLRYAFE----SCDAMLRDSE-TKELTKKSFDLAILDGAFPECFLGLMYD 145
                 ||  |:..|...|...:    .|..:::.|| ..:|..:.|||||.: ||..|..|:...
Worm   100 -----EMSNPLMMWMNPRILTQLFGKQCTKVMKLSELLDQLKSEKFDLAITE-AFDSCGYGIFEY 158

  Fly   146 FKIPFMYINTVGFYTGSISTA---------GNPVSYAITPNFYSRFTDTMNLYERAINTAMQIGQ 201
            .:||        .:...:|.|         |.|::.:..|...|.::|.|.:.:|.:|....:..
Worm   159 LQIP--------AHVSILSCARMDHVSDVLGQPIAPSYVPGTQSLYSDRMTMTQRFLNYLQFLNG 215

  Fly   202 TLMHMYVMRRTHLVMREHLGTQ------IPHPYEMSRNVSFILQNGHAVLSYPRAFNPNVAEVAC 260
            ..|...:........::.||.:      :|..       ||:|.|...||.:|......:..:..
Worm   216 NSMFSDIGDYESANAKKLLGVERSWREILPES-------SFLLTNHIPVLEFPAPTFDKIVPIGG 273

  Fly   261 IHCRPARKLPRNLEEFIG--ASGASGFIYVSMGSSVKAANMPEALRHMLVKTFARLP-YHVLWKY 322
            |... ..|....||.:..  .|.....:.:|.||::|:.:||:..:..|.:.|..:| ...:|||
Worm   274 ISVN-KNKETLKLEHYFDTMVSMRKKNVIISFGSNIKSMDMPDEYKKSLAELFQLMPDVTFIWKY 337

  Fly   323 EGSSTDIKDIT---SNVKLSRWLPQQDILGHPKLRAFVTHGGLLSMFETVYHGVPVVTMPVFCDH 384
            |..:.  |..|   .|:....|:||.::|...::.||:|||||.|:.|....|.|.|.:|:|.|.
Worm   338 ENLAD--KKYTCGIMNINRVEWIPQTELLADSRVDAFITHGGLGSVTELATMGKPAVVIPIFADQ 400

  Fly   385 DVNSAKAEVDGYA---IKLDLQTLSANQLYKAIMKVIHNPRYRNSARHRQKLFLDQRSTALDTAI 446
            ..|:...:..|.|   .|.||  .:...|.|.:.||:.:|.||.:|:...::..:|.:...:|.:
Worm   401 TRNAEMLKRHGGAEVLHKTDL--ANPETLRKTLRKVMDDPSYRQNAQRLAEMLNNQPTNPKETLV 463

  Fly   447 YWTEYVLRHNGAYHLQTPSRNMTWWQYYLLDVVAVYLILL----YVLILAL 493
            ...|:..|......:....|:....:||.||::|:..|||    |:.|.|:
Worm   464 KHVEFAARFGKLPSMDPYGRHQNIIEYYNLDILAIATILLTLVVYLKIFAV 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt50B3	NP_001260710.1	YjiC	28..434	CDD:224732	106/441 (24%)
Ugt50B3	NP_001260710.1	egt	<172..479	CDD:223071	80/321 (25%)
ugt-23	NP_001076755.1	UDPGT	20..526	CDD:278624	122/506 (24%)
ugt-23	NP_001076755.1	Glycosyltransferase_GTB_type	40..474	CDD:299143	110/464 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	161	1.000	Domainoid score	I2438
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	172	1.000	Inparanoid score	I2735
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45374
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.870