DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt50B3 and ugt-6

DIOPT Version :9

Sequence 1:	NP_001260710.1	Gene:	Ugt50B3 / 246614	FlyBaseID:	FBgn0050438	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_001369960.1	Gene:	ugt-6 / 179755	WormBaseID:	WBGene00013904	Length:	533	Species:	Caenorhabditis elegans

Alignment Length:	553	Identity:	120/553 - (21%)
Similarity:	221/553 - (39%)	Gaps:	95/553 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 KIALFLIIWSCGTLAAD-------ILMATQGGTKSHKIPFWELAKGLISRGHNITFLSGFPAD-F 60
            :|.|||.|   .||..:       ::....|  .||.....|||..|...|:::|:...|..| :
Worm     3 QIVLFLFI---STLFGNAYSYKFLVISPVYG--FSHMKYMAELANHLARAGNDVTYFQPFVVDEY 62

  Fly    61 NIEGLLEVTPAGLVEYIHNYTNWDLLGSRMAGEMPIK-----PWDGLRY---------------- 104
            :...|::.....:..|.|     |.||.:   .:|.:     .|....|
Worm    63 HDHTLIKEKSIKIWNYYH-----DELGRQ---HIPSQGCMRDAWHSSWYQSDAGAAILLSKYLFP 119

  Fly   105 AFE-SCDAMLRDSETK-ELTKKSFDLAILDGAFPECFLGLMYDFKIPFMYINTVGFYTGSISTA- 166
            ||| .|..|..|:|.. :|..:.||: :|..||..|.|.|....::|    :.:..:||:...|
Worm   120 AFEHMCRKMFEDTELHYDLKSRQFDV-VLSEAFDFCGLYLASYLEMP----SIISTFTGNRLNAL 179

  Fly   167 ----GNPVSYAITPNFYSRFTDTMNLYERAINTAMQIGQTLMHMYVMRRTHLVMREHLGTQIPHP 227
                |.|......|...|::.....:::|..:...:|..:.....:....:..:.:....::.|.
Worm   180 APVLGEPSFLHYLPAPTSQYGHESTIFDRLNDVWHKIWSSYGFAQLFEMQYQQVSKLTNGKVKHW 244

  Fly   228 YEMSRNVSFILQNGHAVLSYPRAFNPNVAEVACI------------------HCRPARKLPRNLE 274
            .::..:|::...|.:..|.:.....|.|..:..|                  |...|||  .|
Worm   245 KDIIHDVTYHFSNSNPYLDFVIPTIPKVVPIGGITVDHDYWSTNGNHSELLEHVLNARK--HN-- 305

  Fly   275 EFIGASGASGFIYVSMGSSVKAANMPEALRHMLVKTFARLP-YHVLWKYE--GSSTDIKDITSNV 336
                       :::|.||.|::.:||:..:..::|.|:..| ...|||||  .....::.:.:||
Worm   306 -----------VFISFGSMVRSVDMPKEFKKSMMKVFSDHPNITFLWKYELPNDQEFLRILPTNV 359

  Fly   337 KLSRWLPQQDILGHPKLRAFVTHGGLLSMFETVYHGVPVVTMPVFCDHDVNSAKAEVDGYA---I 398
            .:::|..|..:|...::..|||||||.|..|......|.:.:|:|.|...|:...|..|..   .
Worm   360 HVAKWFSQSALLSDQRVNLFVTHGGLGSTMELARAAKPAIVIPLFADQPGNAKMIERHGSVEIFS 424

  Fly   399 KLDLQTLSANQLYKAIMKVIHNPRYRNSARHRQKLFLDQRSTALDTAIYWTEYVLRHNGAYHLQT 463
            |||:.  ::.:|...|.|:::...|:.:|.........|..|..|..:...|...|.....:|..
Worm   425 KLDIP--NSKKLSSLIQKMLNTKYYQQNANRLADTLRFQPITPTDLMVKHAENAARFGKMPNLVP 487

  Fly   464 PSRNMTWWQYYLLDVVAVYLILLYVLILALRRI 496
            .:::|.:::||.:|::.:..:|:::|...:..:
Worm   488 HAKDMGFFEYYNIDIIFIVFLLVWLLFSVVAHV 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt50B3	NP_001260710.1	YjiC	28..434	CDD:224732	100/458 (22%)
Ugt50B3	NP_001260710.1	egt	<172..479	CDD:223071	69/330 (21%)
ugt-6	NP_001369960.1	GT1_Gtf-like	20..456	CDD:340817	101/467 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45374
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.820