DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt50B3 and ugt-1

DIOPT Version :9

Sequence 1:	NP_001260710.1	Gene:	Ugt50B3 / 246614	FlyBaseID:	FBgn0050438	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_505671.1	Gene:	ugt-1 / 179449	WormBaseID:	WBGene00007072	Length:	529	Species:	Caenorhabditis elegans

Alignment Length:	565	Identity:	134/565 - (23%)
Similarity:	232/565 - (41%)	Gaps:	88/565 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LFLIIWS---CGTLAADILMATQGGTKSHKIPFWELAKGLISRGHNITFLSGFP----------- 57
            |||::.|   |  .:.:.|:.:.....||.....::|..|.:..||:|.|..:.
Worm     4 LFLLLTSLTFC--YSHNFLVVSPVFGYSHMKFMNKVADTLANGDHNVTILQTYNYEHFGKIRMAK 66

  Fly    58 ------ADFNIEGLLEVT---PAGLVEYIHN--YTNWDLLG-----SRMAGEMPIKPWDGLRYAF 106
                  .|::::....|:   .|...:|:.|  ..|..:.|     :.:.|||.
Worm    67 NTNVEILDYHLDESKAVSNENSASAFKYMWNTEIINNPITGAIATSTVLYGEMK----------- 120

  Fly   107 ESCDAMLRDSET-KELTKKSFDLAILDGAFPECFLGLMYDFKIPFMYINTVGFYTGSISTAGNPV 170
            ..|:.:|.|.:. |.:..|:|| ..:...|..|.|.|....|:..:.:::......|:...|.|.
Worm   121 TMCEKVLLDKKLHKWILSKNFD-GFISEPFDFCGLYLGDHLKLNIIPMHSSTKSLPSVYAIGEPS 184

  Fly   171 SYAITPNFYSRFTDTMNLYERAINTAMQIGQ-------TLMHMYVMRRTHLVMREHLGTQIPHPY 228
            .....|:..::|.....:::|       ||.       .|....:..:.:....:.|...:.|..
Worm   185 LLNFLPSMRTKFGTEQTVFDR-------IGDIIALPCLELAFSKLFEKQYKQASQLLNGDVRHWK 242

  Fly   229 EMSRNVSFILQNGHAVLSYPRAFNPNVAEVACIHCRPARKLPRNL---EEFIG-ASGASGFIYVS 289
            |:.:..:|...|.:..:::|....|....:......|    |:||   ||:.. .|.....:.:|
Worm   243 EILQTATFYFSNANDFIAFPTPSLPKHVHIGGFTIDP----PKNLKLEEEYNKILSLRKSTVLIS 303

  Fly   290 MGSSVKAANMPEALRHMLVKTFARLP-YHVLWKYEGSSTD-IKDITSNVKLSRWLPQQDILGHPK 352
            .|:.:::|:|||:.:..::|.|..|| ...:||||..... |:.:.:|..|.:|:||..:|..|:
Worm   304 FGTVIQSADMPESFKDGIIKMFHLLPDTTFIWKYEVEDQQFIERLPNNAILKKWVPQPALLADPR 368

  Fly   353 LRAFVTHGGLLSMFETVYHGVPVVTMPVFCDHDVNSAKAEVDGYAI---KLDLQTLSANQLYKAI 414
            |:.|||||||.|..|..|.|.|.:.:|||.|..:|:......|.|.   |.||:  .|.:|..||
Worm   369 LKLFVTHGGLGSTLEVAYSGKPALMIPVFGDQLLNAKMLSRHGGATVFDKYDLE--DAEKLTSAI 431

  Fly   415 MKVIHNPRYRNSARHRQKLFLDQRSTALDTAIYWTEYVLRHNGAYHLQTPSRNMTWWQYYLLDVV 479
            .::|.|..:...:.|...|..:|........:...|:..:......|:..:.:..:.|||:||..
Worm   432 KEIIGNEEFNKKSHHIADLLRNQPIDPKANLLKHVEFSAKFGRVDALEPYNVHYNFVQYYMLDAF 496

  Fly   480 A-VYLILLYVLILALRRIDFPYEKVRSLYSLMAPFITIAKTKSKK 523
            | ::.||:.:..||.....|.|:.|             .||||||
Worm   497 AIIFSILIIIFYLAHLLFKFVYKHV-------------FKTKSKK 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt50B3	NP_001260710.1	YjiC	28..434	CDD:224732	105/449 (23%)
Ugt50B3	NP_001260710.1	egt	<172..479	CDD:223071	81/322 (25%)
ugt-1	NP_505671.1	UDPGT	28..528	CDD:278624	126/537 (23%)
ugt-1	NP_505671.1	egt	<190..494	CDD:223071	79/316 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45374
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.820