DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt50B3 and ugt-49

DIOPT Version :9

Sequence 1:	NP_001260710.1	Gene:	Ugt50B3 / 246614	FlyBaseID:	FBgn0050438	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_505666.2	Gene:	ugt-49 / 179446	WormBaseID:	WBGene00007070	Length:	525	Species:	Caenorhabditis elegans

Alignment Length:	566	Identity:	144/566 - (25%)
Similarity:	238/566 - (42%)	Gaps:	96/566 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LFLIIWSCGTLAADILMATQGGTKSHKIPFWELAKGLISRGHNIT-FLSGFPADFNIEGLLEVTP 70
            |||::......|..||:.:...::||.|....:|..|:..||::. |::.:      |.|.|.|
Worm     5 LFLLLSLLAVDAGKILVYSPSISRSHLISNGRIADALVDAGHDVVMFITEY------EPLTEFT- 62

  Fly    71 AGLVEYIHNYTNWDLLGSRMAGEMPIKPW--------DGL--------------RYAFE-----S 108
                            |::.|..:.:|.:        ||:              |..||     :
Worm    63 ----------------GTKKAKVITMKGFSTKFAEDMDGIGEYLLSSSRLSFLERLMFEKTCTGA 111

  Fly   109 C-DAMLRDSETKELTKKSFDLAILDGAFPE----CFLGLMYDFKIP-FMYINTVGFYTGSISTAG 167
            | |.|.|..|.::|...:||:     ||.|    |.:|::....|. .::|:|...........|
Worm   112 CDDLMTRREELEQLRAYNFDV-----AFSEQIDLCGVGIVRYLGIKNHLWISTTPIMDAVSYNLG 171

  Fly   168 NPVSYAITPNFYSRFT-DTMNLYERAINTAMQIGQTLMHMYVMRRTHLVMREHLGTQIPHPYEMS 231
            .|...:..|....... |.|:.::|..|..|:||..|:|.|....|..|.|::: ...|:..|::
Worm   172 IPAPSSYVPTIEENDNGDKMDFWQRTFNLYMKIGSILIHRYGTDGTTEVFRKYI-PDFPNVREIA 235

  Fly   232 RNVSFILQNGHAVLSYPRAFNPNVAEVACIHCRPARKLPRNLEE---FIGASGASGFIYVSMGSS 293
            .|.|....|...||..||   |.:.:...:......|:.:.|::   .|.:.|..|.:.:|:||.
Worm   236 ANSSLCFVNSDEVLDLPR---PTITKAIYVGGLGIPKVSKPLDKKFTNIMSKGKEGVVIISLGSI 297

  Fly   294 VKAANMPEALRHMLVKTFARL-PYHVLWKYEGSSTDIKDIT---SNVKLSRWLPQQDILGHPKLR 354
            :...::|.|.:..:::....: .||.|.|......:.|.:.   .||.::.||||.|||.||:|:
Worm   298 IPFGDLPAAAKEGVLRAIQEISDYHFLIKIAKGDNNTKKLVEGIKNVDVAEWLPQVDILSHPRLK 362

  Fly   355 AFVTHGGLLSMFETVYHGVPVVTMPVFCDHDVNSAKAEVDGYA---IKLDLQTLSANQLYKAIMK 416
            .||.|||:..:.||....||.|.:|||.|...|....|..|..   :|||   :........::.
Worm   363 LFVMHGGINGLVETAIQAVPTVIVPVFADQFRNGRMVEKRGIGKVLLKLD---IGYESFKNTVLT 424

  Fly   417 VIHNPRYRNSARHRQKLFLDQRSTALDTAIYWTEYVLRHNGAYHLQTPSRNMTWWQYYLLDVVA- 480
            |::.|.|:.:|....|:..|:..:..:....||::.:.|.....|......:....||.|||:|
Worm   425 VLNTPSYKKNAIRIGKMMRDKPFSPEERLTKWTQFAIDHGVLEELHVEGSRLNTIIYYNLDVIAF 489

  Fly   481 ---VYLILLYVLILALRRIDFPYEKVRSLYSLMAPFITIAKTKSKK 523
               |::.:|:|.|.|.:   |...|.||..::         .||||
Worm   490 VLFVFVAVLHVFIYAFK---FLCCKKRSQSNI---------KKSKK 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt50B3	NP_001260710.1	YjiC	28..434	CDD:224732	114/450 (25%)
Ugt50B3	NP_001260710.1	egt	<172..479	CDD:223071	85/317 (27%)
ugt-49	NP_505666.2	UDPGT	17..523	CDD:278624	138/552 (25%)
ugt-49	NP_505666.2	egt	<162..464	CDD:223071	81/308 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45374
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14680
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.820