DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt50B3 and ugt-48

DIOPT Version :9

Sequence 1:	NP_001260710.1	Gene:	Ugt50B3 / 246614	FlyBaseID:	FBgn0050438	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_504464.2	Gene:	ugt-48 / 178940	WormBaseID:	WBGene00015965	Length:	526	Species:	Caenorhabditis elegans

Alignment Length:	565	Identity:	133/565 - (23%)
Similarity:	238/565 - (42%)	Gaps:	82/565 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLKKIALFLIIWSCGTLAADILMATQGGTKSHKIPFWELAKGLISRGHNITFLSGFPADFNIEGL 65
            ||.:|..||.:... |.:..|||.:...:|||.|....:|..|.:.||.:.   .|..||
Worm     1 MLLRILTFLAVCQV-TTSHKILMFSPTASKSHMISQGRIADELANAGHEVV---NFEPDF----- 56

  Fly    66 LEVTPAGL---------VEYIHNYTNWDLLGSRMAGEM--------PIKPWDGLRYAFE---SCD 110
            |.:|...:         |..::|| .:..:.:.::|::        .|...|...|..|   .|:
Worm    57 LNLTDKFVPCKKCRRWPVTGLNNY-KFKKIQNGLSGDVFQQSSIWSKIFNTDSDPYQDEYTNMCE 120

  Fly   111 AMLRDSE-TKELTKKSFDLAILDGAFPECFLGLMYDFKIPFMYINTVGFYTGSIS---TAGNPVS 171
            .|:.:.| .::|.|:.|| |........|.:||.:...|...:  .:...|.|:|   :.|.|
Worm   121 EMVTNKELIEKLKKEKFD-AYFGEQIHLCGMGLAHLIGIKHRF--WIASCTMSVSMRDSLGIP-- 180

  Fly   172 YAITPNFYSRFTDTMN-----LYERAINTAMQIGQTLMHMYVMRRTHLVMREHLGTQIPHPYEMS 231
               ||:....|..|::     .::||.|..:|:.........:..|:.:.:::.|:..|....::
Worm   181 ---TPSSLIPFMSTLDATPAPFWQRAKNFVLQMAHIRDEYRDVVLTNDMFKKNFGSDFPCVEFLA 242

  Fly   232 RNVSFILQNGHAVLSYPRAFNPNVAEVACIHCRPA-----RKLPRNLEEFIGASGASGFIYVSMG 291
            :....|..:...:|........||..:..:.....     .|..:.:|:      ..|.|..|:|
Worm   243 KTSDLIFVSTDELLEIQAPTLSNVVHIGGLGLSSEGGGLDEKFVKIMEK------GKGVILFSLG 301

  Fly   292 SSVKAANMPEALRHMLVKTFARL-PYHVLW---KYEGSSTDIKDITSNVKLSRWLPQQDILGHPK 352
            :.....|:|..:...|:|...:. .|..:.   |::..|.|:.:..|||.:..|:||..:|.||:
Worm   302 TIANTTNLPPTIMENLMKITQKFKDYEFIIKVDKFDRRSFDLAEGLSNVLVVDWVPQTAVLAHPR 366

  Fly   353 LRAFVTHGGLLSMFETVYHGVPVVTMPVFCDHDVNSAKAEVDGYAIKLDLQTL--SANQLYKAIM 415
            |:||:||.|..|:.|:.|.||||:.:|...|...|....|..|:.|..|...|  ..:.:..||.
Worm   367 LKAFITHAGYNSLMESAYAGVPVILIPFMFDQPRNGRSVERKGWGILRDRFQLIKDPDAIEGAIK 431

  Fly   416 KVIHNPRYRNSARHRQKLFLDQRSTALDTAIYWTEYVLRHNGAYHLQTPSRNMTWWQYYLLDVV- 479
            :::.||.|:..|...:||...:..:|.:..:..|.:||.::|...||...::|.::.:|.||::
Worm   432 EILVNPTYQEKANRLKKLMRSKPQSASERLVKMTNWVLENDGVEELQYEGKHMDFFTFYNLDIII 496

  Fly   480 -AVYLILLYVLILALRRIDFPYEKVRSLYSLMAPFITIAKTKSKK 523
             |..:.:|..::|.:..|.                |..:..|:||
Worm   497 TAASIPVLIFIVLRISNIS----------------IITSSPKNKK 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt50B3	NP_001260710.1	YjiC	28..434	CDD:224732	104/445 (23%)
Ugt50B3	NP_001260710.1	egt	<172..479	CDD:223071	78/322 (24%)
ugt-48	NP_504464.2	UDPGT	19..510	CDD:278624	121/513 (24%)
ugt-48	NP_504464.2	egt	<224..471	CDD:223071	62/252 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45374
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.820