DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt50B3 and ugt-11

DIOPT Version :9

Sequence 1:	NP_001260710.1	Gene:	Ugt50B3 / 246614	FlyBaseID:	FBgn0050438	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_504311.1	Gene:	ugt-11 / 178882	WormBaseID:	WBGene00020593	Length:	533	Species:	Caenorhabditis elegans

Alignment Length:	542	Identity:	120/542 - (22%)
Similarity:	215/542 - (39%)	Gaps:	96/542 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LIIWSC------GTLAADILMATQGGTKSHKIPFWELAKGLISRGHNITFLSGFP-ADFNIEGLL 66
            |:.:||      ...||.||:.......||.....:||..:...|..:|....|. |..|::|::
Worm     3 LLTFSCLCFLLKVNYAAKILIFNPIFGFSHVKFVSKLADIIADHGQEVTLFQPFHLALKNLDGIV 67

  Fly    67 EVTPAGLVEYIHNYTN-------------WD------------LLGSRMAGEMPIKPWDGLRYAF 106
            :.....::.|..::.:             ||            :|...:.||..
Worm    68 KNKNIEIINYYPDHYDDLLKLETQTFPDFWDSQLMNNPVLMAFMLPRILGGEFK----------- 121

  Fly   107 ESCDAMLRDSE-TKELTKKSFDLAI-----LDGAFPECFLGL----------MYDFKIPFMYINT 155
            ::...:::|.| .|:|..|.||:||     |.|.:...|||:          :..|...|...:.
Worm   122 KTTIQLIKDKEILKKLKDKKFDVAISETFELTGMYMSHFLGVPCIPILSAVRLDIFNEAFGQSSA 186

  Fly   156 VGFYT--GSISTAGNPVSYAITPNFYSRFTDTMNLYERAINTAMQIGQTLMHMYVMRRTHLVMRE 218
            .|:.|  ||          .:.|:  :.|.|.:|...|...:.|.......:.      :.|:.:
Worm   187 FGYLTQQGS----------KLAPD--AGFLDRLNDVYRDFFSKMAFRGMAQYQ------NDVIEK 233

  Fly   219 HLGTQIPHPYEMSRNVSFILQNGHAVLSYPRAFNPNVAEVACIHCRPAR-----KLPRNLEEFIG 278
            ..|..:|:..::.:.....:.|.:..|.:.......:..:..|.....:     .||...|..:.
Worm   234 AAGHVVPYWKDLVKEAPVYMTNSNPYLDFAVPTTATIVHIGGITINLEKMNHVDALPEEYEIILK 298

  Fly   279 ASGASGFIYVSMGSSVKAANMPEALRHMLVKTFARLPYHV-LWKYEGSSTDI-KDITSNVKLSRW 341
            ....:  :.:|.||.:::..|||..:..|:|.|..||..: :||||....:. |.:..||.|.:|
Worm   299 EKETT--VLISFGSVIRSYEMPENFKAGLIKVFESLPDVIFIWKYEIDDLEFQKKLPKNVHLKKW 361

  Fly   342 LPQQDILGHPKLRAFVTHGGLLSMFETVYHGVPVVTMPVFCDHDVNSAKAEVDGYAI---KLDLQ 403
            :||..:|...:::.|||||||.|..|..|.|.|.:.:|:|.|..:|:......|.||   |.||
Worm   362 VPQPSLLADKRVKLFVTHGGLGSTMEVAYTGKPALMVPIFGDQPMNADMLARHGGAIAYDKFDL- 425

  Fly   404 TLSANQLYKAIMKVIHNPRYRNSARHRQKLFLDQRSTALDTAIYWTEYVLRHNGAYHLQTPSRNM 468
             :...:|.:.:..::.||:|...|:....:..:|....:...:...|:.::... ...|.|..|.
Worm   426 -VDGKKLTETVRDLVTNPKYEQKAKELLDVLTNQPIDPVMNLMKHLEFAIKFPN-LRSQIPEINQ 488

  Fly   469 TW-WQYYLLDVVAVYLILLYVL 489
            .. ..:|.|||: |:||.:.::
Worm   489 VGPIAHYYLDVI-VFLIFVSII 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt50B3	NP_001260710.1	YjiC	28..434	CDD:224732	101/459 (22%)
Ugt50B3	NP_001260710.1	egt	<172..479	CDD:223071	73/317 (23%)
ugt-11	NP_504311.1	egt	<220..514	CDD:223071	71/302 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45374
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.820