DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt50B3 and ugt-29

DIOPT Version :9

Sequence 1:	NP_001260710.1	Gene:	Ugt50B3 / 246614	FlyBaseID:	FBgn0050438	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_001370778.1	Gene:	ugt-29 / 178581	WormBaseID:	WBGene00021709	Length:	536	Species:	Caenorhabditis elegans

Alignment Length:	581	Identity:	136/581 - (23%)
Similarity:	233/581 - (40%)	Gaps:	104/581 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLKKIALFLIIWSCGTLAADILMATQGGTKSHKIPFWELAKGLISRGHNITFLSGFPADFNIEGL 65
            ||....:|.::: |.:.:.:||:.:.....||.....:||..|..||||:|:            |
Worm     1 MLLNSLIFTLLF-CSSSSLNILVYSPAYAASHSNFLGKLADTLTERGHNVTY------------L 52

  Fly    66 LEVTPAGLVEYIHNYTNWDLLGSRMAGEMPIKPWDGLRYAFESCDAMLRDSETKELTKKS----- 125
            :.|...|..:        :.:|.::..::.|...|....:.|  :.:..|.|..||..||
Worm    53 MPVMDPGKRD--------ECIGVKLTKDLVIVEADEEMMSRE--EGVTLDEEIMELYWKSEMDSS 107

  Fly   126 ----------------------------------FDLAILDGAFPECFLGLMYDFKI-PFMYINT 155
                                              ||:||:: ....|.||.:....| ..:..::
Worm   108 NSRDMFSFFNNAMKAACRNFLKRRDIFEQMKSRNFDVAIVE-PLSVCGLGFVKALGIEKTILASS 171

  Fly   156 VGFYTGSISTAGNPVSYAITPNFYSRFTDTMNLYER----AINTAMQIG-----QTLMHMYVMRR 211
            ..||...:...|.|:.::..|..:|...|.|.:.||    .:...:.||     ...|..|
Worm   172 CTFYDSIMDYIGEPLDFSYVPALFSVTGDVMTMSERYENWMVTKEINIGIHEKFDDEMKSY---- 232

  Fly   212 THLVMREHLGTQIPHPYEMSRNVSFILQNGHAVLSYPRAFNPNVAEVACIHCR----PARKLPRN 272
                 ||.||..:|...|:....|....|.:....:||........:..|...    ..:||.::
Worm   233 -----REFLGQDLPDWRELLSTASIFFINSNPFFDFPRPVLQKTVPIGGISVNLKWIKEQKLTKD 292

  Fly   273 LEEFIGASGASGFIYVSMGSSVKAANMPEALRHMLVKTFARLP-YHVLWKYEGSSTDIKDITSNV 336
            .||.:.....:  :.:|.||.||:|.||:..|:.|:.....:| ...:||||.......|..||:
Worm   293 WEEVLEMRKKT--VLISFGSLVKSAYMPKKWRNGLLDVIKSMPDVTFIWKYETDDVSFADGVSNI 355

  Fly   337 KLSRWLPQQDILGHPKLRAFVTHGGLLSMFETVYHGVPVVTMPVFCDHDVNS---AKAEVDGYAI 398
            ..|:|:||..:|..|:|..|||||||.|..|..|.|.|.|.:|||.|...|:   |:.....|..
Worm   356 HFSKWVPQTALLNDPRLSVFVTHGGLGSTMELAYSGKPAVVIPVFADQIRNANMIARHRGVIYLH 420

  Fly   399 KLDLQTLSANQLYKAIMKVIHNPRYRNSARHRQKLFLDQRSTALDTAIYWTEYVLRHNGAYHLQT 463
            |..::.:...:  ||...|:.:..|:.:|.....:.::|..:..:..|.:||::..|....::..
Worm   421 KNSMENVKVTR--KAFTDVLFDDSYQKNAEKLANILMNQPYSPKENVIKYTEFLGEHGPFPNMDP 483

  Fly   464 PSRNMTWWQYYLLDVVAVY-LILLYVLILALRRIDFPYEKVRSLYSLMAPFITIAKTKSKK 523
            ..|::.::|...||:..:: |..::|..:.:..|.|.|:..|..:.|:         |||:
Worm   484 HGRHLNYFQKTFLDIYTLFALFYIFVSTIIIVTIRFVYKFTRKHFILV---------KSKE 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt50B3	NP_001260710.1	YjiC	28..434	CDD:224732	111/462 (24%)
Ugt50B3	NP_001260710.1	egt	<172..479	CDD:223071	85/323 (26%)
ugt-29	NP_001370778.1	GT1_Gtf-like	18..468	CDD:340817	115/485 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	172	1.000	Inparanoid score	I2735
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45374
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.870