DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt50B3 and ugt-60

DIOPT Version :9

Sequence 1:	NP_001260710.1	Gene:	Ugt50B3 / 246614	FlyBaseID:	FBgn0050438	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_001021158.1	Gene:	ugt-60 / 176366	WormBaseID:	WBGene00007402	Length:	507	Species:	Caenorhabditis elegans

Alignment Length:	520	Identity:	125/520 - (24%)
Similarity:	225/520 - (43%)	Gaps:	83/520 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 ILMATQGGTKSHKIPFWELAKGLISRGHNITFLSGFPADFNIEGLLEV----TPAGLVEY---IH 78
            ||....|.|.||.:..:.||:.|...||::...:....     .:|:.    .|.|:.||   ||
Worm    18 ILQIVPGFTNSHVLFNYRLAETLRFLGHDVKMWTQMEM-----AMLDTGNNKLPEGVSEYRIPIH 77

  Fly    79 NYTNWDLLGSRMAGEMPIKP-------WDGLRY---AFESCDAMLRDSET--KELTKKSFDLAIL 131
            ........|.::...|..:.       |.|..:   ..|:|:.|||..|:  ::..|..||:||
Worm    78 FTDTLKTEGLKVFQSMMFESGDAHDLWWTGQEFKDMRVEACEQMLRHDESVYEDFRKDGFDVAI- 141

  Fly   132 DGAFPE-CFLGL-----------------MYDFKIPFMYINTVGFYTGSISTAGNPVSYAITPNF 178
             ..|.: |.|.:                 :|:|....:.:.|:.      ||..:|:|.|   .|
Worm   142 -AHFHDLCPLAIAKKMNVKRVIWITHGTSIYEFSAVQLGLRTIP------STIPHPLSSA---GF 196

  Fly   179 YSRFTDTMNLYERAINTAMQIGQTLMHMYVMR----------RTHLVMREHLGTQIPHPYEMSR- 232
            ...|.|             ::..||.|:.::.          ..:|..||.:|......:::::
Worm   197 SQLFLD-------------RVQNTLWHLSLLDFVNLPQNLLVDENLFYREFVGADQDDLWDLAKT 248

  Fly   233 NVSFILQNGHAVLSYPRAFNPNVAEVACIHCRPARKL--PRNLEEFIGASGASGFIYVSMGSSVK 295
            .|..:|.||..:|.:||....::|....:.....:||  .:.||:.| ...:.|.|..|:|:...
Worm   249 TVPSLLINGDRMLDFPRPLPIHIAFSGELGVSKGKKLVMEKWLEDII-EKPSDGLIVFSLGTVSN 312

  Fly   296 AANMPEALRHMLVKTFARL-PYHVLWKYEGSSTDIKDITSNVKLSRWLPQQDILGHPKLRAFVTH 359
            ..|||..:.:..:..|.:| .|.:||:.|.|....:.. .|:.|.:||||:||:.|||::..:.|
Worm   313 TTNMPAQMINSFLGAFGKLKTYTILWRMEKSVAGAEKY-ENLHLVKWLPQKDIMRHPKMKLMIAH 376

  Fly   360 GGLLSMFETVYHGVPVVTMPVFCDHDVNSAKAEVDGYAIKLDLQTLSANQLYKAIMKVIHNPRYR 424
            ||..|..|....|:|.|.||:|.|..:|:.:|:..|.|..||...|:.|.:|.||.:.: .|.|.
Worm   377 GGYNSFLEAAQAGIPAVLMPLFADQKINAKRAQRYGMATVLDKLDLTINNVYGAIKEAL-KPEYS 440

  Fly   425 NSARHRQKLFLDQRSTALDTAIYWTEYVLRHNGAYHLQTPSRNMTWWQYYLLDVVAVYLILLYVL 489
            .:|:....:..||.:....:|:.::..:............|:::::.:::.||:.::.|:..:::
Worm   441 TNAKKLSAMLSDQVARKPYSALRYSLKLATSPKPSLFTLKSQHLSFLEFHNLDIFSIVLLTAFIV 505

Fly 490 489
Worm 506 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt50B3	NP_001260710.1	YjiC	28..434	CDD:224732	115/456 (25%)
Ugt50B3	NP_001260710.1	egt	<172..479	CDD:223071	81/320 (25%)
ugt-60	NP_001021158.1	Glycosyltransferase_GTB_type	17..>161	CDD:299143	36/149 (24%)
ugt-60	NP_001021158.1	egt	<253..464	CDD:223071	66/213 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910