DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt50B3 and ugt-25

DIOPT Version :9

Sequence 1:	NP_001260710.1	Gene:	Ugt50B3 / 246614	FlyBaseID:	FBgn0050438	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_491438.1	Gene:	ugt-25 / 172087	WormBaseID:	WBGene00015692	Length:	531	Species:	Caenorhabditis elegans

Alignment Length:	561	Identity:	133/561 - (23%)
Similarity:	240/561 - (42%)	Gaps:	82/561 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ALFLIIWSCGTLAADILMATQGGTKSHKIPFWELAKGLISRGHNITFLSGFP-ADFNIEGLLEVT 69
            ::|:::......|.:||:.:.....||......||..|...|||:||:  .| ||...:|.|.|.
Worm     5 SVFILLSVINVNAFNILVYSPSFGGSHTNFMARLADTLTEAGHNVTFV--VPVADEARKGQLGVK 67

  Fly    70 PAGLVEYIHNYTNWDLLGSRMAGEMPIKP--------W---------DGLRYAFE-----SCDAM 112
            ....|..:...   :|:.|.      |||        |         |.:...|.     ||:..
Worm    68 KTKDVVIVEQD---ELMKSE------IKPLDDDMAQYWETDMDSSNADSIFSVFSDAMLLSCNNF 123

  Fly   113 LRDSET-KELTKKSFDLAILDGAFPECFLGLMYDFKI-PFMYINTVGFYTGSISTAGNPVSYAIT 175
            :|:.:. .||..::||:.|.: ....|.||.|:...| ..:..::...|.|:::..|.|:.::..
Worm   124 MRNKKVFNELKSRNFDVGIYE-PLSVCGLGYMHAIGINKLIMSSSCALYDGTVAAIGEPIDFSYV 187

  Fly   176 PNFYSRFTDTMNLYERAINTAMQIGQTLMHMYVMRRTHLVMREHLGTQIPHPYEMSRNVSFILQN 240
            |...|:..:.|:|:|:..|..:.:..:.|......:...:.::|||..|||..::..:.|....|
Worm   188 PGSMSKSGEKMSLFEKLENYRLSMASSRMQYGQWDKETEIYKKHLGNDIPHWRDLMPSSSVAFTN 252

  Fly   241 GHAVLSYPRAFNPNVAEVACI----HCRPARKL-----------PRNLEEFIGASGASGFIYVSM 290
            ....:.:||:.......:..|    ....::||           |.|:             .:|.
Worm   253 SIPYVDFPRSITQKTVPIGGISVDMEMIKSQKLSIEWSTVLDERPHNM-------------LISF 304

  Fly   291 GSSVKAANMPEALRHMLVKTFARLP-YHVLWKYEGSSTDIKDITSNVKLSRWLPQQDILGHPKLR 354
            ||.|::.:||...|:.|::.....| ...:||||..:.:......|:..|:|:||..:|...:|.
Worm   305 GSMVRSMDMPLKWRNGLLEAIKSEPNVTFIWKYENDNLEWAKGIQNIYFSKWVPQTALLNDARLT 369

  Fly   355 AFVTHGGLLSMFETVYHGVPVVTMPVFCDHDVNSAKAEVDGYAIKLDLQTLSANQLYK-AIMKVI 418
            ||:|||||.|..|..:.|.|.:.:|||.|.|.|:......|..:.:..:.|...:..| :|..::
Worm   370 AFMTHGGLGSTNELAFLGKPALMVPVFADQDRNANMLARHGGVLVVHKKELGNFKTIKSSIRSIL 434

  Fly   419 HNPRYRNSARHRQKLFLDQRSTALDTAIYWTEYVLRHNGAYHLQTPSRNMTWWQYYLLDVVAVYL 483
            |..:|:.:||...:|..:|.....:..:.:||:|.:......:.:..|.:.:.|..|:|:.|. :
Worm   435 HEEKYQKNARKLSELLNNQPLKPKEQVVKYTEFVAKFGPFPQMDSYGRQLGFIQRNLIDIYAA-I 498

  Fly   484 ILLYVLILALRRIDFPYEKVRSLYSLMAPFITIAKTKSKKI 524
            .|.|:.:::|  |.|.::.|            |:||..|.:
Worm   499 SLSYLFVISL--IYFVFKFV------------ISKTPLKLV 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt50B3	NP_001260710.1	YjiC	28..434	CDD:224732	109/447 (24%)
Ugt50B3	NP_001260710.1	egt	<172..479	CDD:223071	76/323 (24%)
ugt-25	NP_491438.1	egt	1..477	CDD:223071	118/496 (24%)
ugt-25	NP_491438.1	UDPGT	29..530	CDD:278624	129/537 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	172	1.000	Inparanoid score	I2735
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45374
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.870