DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt50B3 and UGT3A2

DIOPT Version :9

Sequence 1:	NP_001260710.1	Gene:	Ugt50B3 / 246614	FlyBaseID:	FBgn0050438	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	XP_011512290.1	Gene:	UGT3A2 / 167127	HGNCID:	27266	Length:	550	Species:	Homo sapiens

Alignment Length:	531	Identity:	147/531 - (27%)
Similarity:	232/531 - (43%)	Gaps:	85/531 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 AADIL-MATQGGTKSHKIPFWELAKGLISRGHNITFLSGFPADFNIEGLLEVTPAGL-----VEY 76
            ||.|| ::|.||  ||.:....:::.|...|||:|.|:.....| :.||.: :||..     :.|
Human    22 AAKILTISTVGG--SHYLLMDRVSQILQDHGHNVTMLNHKRGPF-MPGLSD-SPASASRYPRILY 82

  Fly    77 IHNYTNWDL------------------------------------LGSRMAGEMPIKPWDGLRYA 105
            :..|..:.|                                    ||.|...|..:   :.|.|.
Human    83 LQKYCQFGLKDFKKEEKSYQVISWLAPEDHQREFKKSFDFFLEETLGGRGKFENLL---NVLEYL 144

  Fly   106 FESCDAMLRDSETKE-LTKKSFDLAILDGAFPECFLGLMYDFKIPFMYINTVGFYTGSISTAGNP 169
            ...|...|...:..: |..::||:.|:: .|..|...:......||:.|.:..|  ||:. .|.|
Human   145 ALQCSHFLNRKDIMDSLKNENFDMVIVE-TFDYCPFLIAEKLGKPFVAILSTSF--GSLE-FGLP 205

  Fly   170 VSYAITPNFYSRFTDTMNLYERAINTAMQIGQTLMHMYVMRRTHL------VMREHLGTQIPHP- 227
            :..:..|.|.|..||.|:.:.|..|..|      ...:..|:.|:      .::||. |:...|
Human   206 IPLSYVPVFRSLLTDHMDFWGRVKNFLM------FFSFCRRQQHMQSTFDNTIKEHF-TEGSRPV 263

  Fly   228 ---YEMSRNVSFILQNGHAVLSYPRAFNPNVAEVACIHCRPARKLPRNLEEFIGASGASGFIYVS 289
               ..:...:.||  |......:.|...||...|..:..:|.:.:|::||.||...|.|||:.|:
Human   264 LSHLLLKAELWFI--NSDFAFDFARPLLPNTVYVGGLMEKPIKPVPQDLENFIAKFGDSGFVLVT 326

  Fly   290 MGSSVKAANMPEALRHMLVKTFARLPYHVLWKYEGSSTDIKDI--TSNVKLSRWLPQQDILGHPK 352
            :||.|.....||..:.| ...||.||..|:||.:.|... ||:  .:|||:..||||.|:|.||.
Human   327 LGSMVNTCQNPEIFKEM-NNAFAHLPQGVIWKCQCSHWP-KDVHLAANVKIVDWLPQSDLLAHPS 389

  Fly   353 LRAFVTHGGLLSMFETVYHGVPVVTMPVFCDHDVNSAKAEVDGYAIKLDLQTLSANQLYKAIMKV 417
            :|.||||||..|:.|.:.||||:|.:|:|.|...|..:.|...:.:.:.|:.|.|..|...:.::
Human   390 IRLFVTHGGQNSIMEAIQHGVPMVGIPLFGDQPENMVRVEAKKFGVSIQLKKLKAETLALKMKQI 454

  Fly   418 IHNPRYRNSARHRQKLFLDQRSTALDTAIYWTEYVLRHNGAYHLQTPSRNMTWWQYYLLDVVAVY 482
            :.:.||:::|.....:......:.....:.|.::||:..||.||:.......|.:.|||||
Human   455 MEDKRYKSAAVAASVILRSHPLSPTQRLVGWIDHVLQTGGATHLKPYVFQQPWHEQYLLDV---- 515

  Fly   483 LILLYVLILAL 493
                :|.:|.|
Human   516 ----FVFLLGL 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt50B3	NP_001260710.1	YjiC	28..434	CDD:224732	125/459 (27%)
Ugt50B3	NP_001260710.1	egt	<172..479	CDD:223071	98/318 (31%)
UGT3A2	XP_011512290.1	UDPGT	23..518	CDD:278624	143/524 (27%)
UGT3A2	XP_011512290.1	egt	<162..517	CDD:223071	112/377 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45374
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.820