DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt50B3 and ugt2b5

DIOPT Version :9

Sequence 1:	NP_001260710.1	Gene:	Ugt50B3 / 246614	FlyBaseID:	FBgn0050438	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_001170816.2	Gene:	ugt2b5 / 100384902	ZFINID:	ZDB-GENE-100402-3	Length:	527	Species:	Danio rerio

Alignment Length:	569	Identity:	158/569 - (27%)
Similarity:	262/569 - (46%)	Gaps:	107/569 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LIIWSCGTLAADILMATQGGTKSHKIPFWELAKGLISRGHNIT--------FLSGFPAD------ 59
            |.::|.|.....::..|:|   ||.|....:...|:.||||:|        |:....:|
Zfish    11 LTVFSAGQCGNILVWYTEG---SHWINLKIVLDTLLDRGHNVTVLVPDGALFMKAKESDRFSYQH 72

  Fly    60 FNIE----------------GLLEVTPAGLVEYIHNYTNWDLLGSRMAGEMPIKPWDGLRYAFES 108
            |::.                .:.|:..:..:|....:.|   |||:.. :|      .|.|
Zfish    73 FSVSKSAQDMQDFFDELMRFSVFEMDNSSFLEIQMKFFN---LGSQHQ-DM------SLSY---- 123

  Fly   109 CDAMLRDSETKELTKK-SFDLAILDGAFP-------ECFLGLMYDFKIPFMYINTVGFYTGSIST 165
            ||.:|:..|..:..|| .||:.:.|..:|       |..:.|:|.|:  |...:......|.|..
Zfish   124 CDGILKSPELMDKLKKGKFDVVLSDPMYPCSDIVAEELNVPLVYTFR--FSVAHAAERMCGQIPA 186

  Fly   166 AGNPVSYAITPNFYSRFTDTMNLYERAINTAMQIGQTLMHMYVMRRTHLVMREHLGTQIPHPYEM 230
               |.||  .|...|:.||.|:..||..|....:.|..:...:.||......|:.|
Zfish   187 ---PPSY--VPGAMSKLTDKMSFTERIFNMLFYLSQDTLSRLIWRRFDNYYTEYFG--------- 237

  Fly   231 SRNVSFILQNGHAVL---------SYPRAFNPNVAEVACIHCRPARKLPRNLEEFIGASGASGFI 286
             |:.|:....|.|.:         .:||.|.||...:..:||.||:.||:::|||:.:||..|.:
Zfish   238 -RSTSYCEMMGKADIWLIRTYWDFEFPRPFVPNFKYIGGLHCTPAKPLPKDMEEFVQSSGDDGIV 301

  Fly   287 YVSMGSSVKAANMPEALRHMLVKTFARLPYHVLWKYEGSSTDIKDITSNVKLSRWLPQQDILGHP 351
            ..::||.:.  .:|:.:.:.:....|::|..|||:|.|...|  .:..|.::.:|:||.|:||||
Zfish   302 VFTLGSMID--KVPKEMSNRIASALAQIPQKVLWRYGGEKPD--TLGENTRIYKWIPQNDLLGHP 362

  Fly   352 KLRAFVTHGGLLSMFETVYHGVPVVTMPVFCDHDVNSAKAEVDGYAIKLD-LQTLSANQLYKAIM 415
            |.|||:||||...::|.:|||||:|.:|:|.|...|.........|:.:| ::::...:|...:.
Zfish   363 KTRAFITHGGTNGVYEAIYHGVPMVGIPLFGDQPDNMVHMTTRAAAVVVDSIKSMQPQELVDKLN 427

  Fly   416 KVIHNPRYRNSARHRQKLFLDQRSTALDTAIYWTEYVLRHNGAYHLQTPSRNMTWWQYYLLDVVA 480
            .||::|.|:.:|....::..|:....||.:::|.|:|:|:.||.||:..:.|:||:||:.|||.|
Zfish   428 TVINDPSYKENAMRLSRIHHDRPMKPLDESVFWIEFVMRNKGAKHLRVEAHNLTWYQYHCLDVFA 492

  Fly   481 -VYLILLYVLILALRRIDFPYEKVRSLYSLMAPFITI-----AKTKSKK 523
             :..:|..||.:..:               ||.|..:     :|.||||
Zfish   493 FLTTVLTLVLYICFK---------------MAKFFIMRCCFRSKRKSKK 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt50B3	NP_001260710.1	YjiC	28..434	CDD:224732	122/453 (27%)
Ugt50B3	NP_001260710.1	egt	<172..479	CDD:223071	100/316 (32%)
ugt2b5	NP_001170816.2	UDPGT	20..523	CDD:278624	151/555 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.810