DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt50B3 and ugt5e1

DIOPT Version :9

Sequence 1:	NP_001260710.1	Gene:	Ugt50B3 / 246614	FlyBaseID:	FBgn0050438	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	XP_005166829.1	Gene:	ugt5e1 / 100002993	ZFINID:	ZDB-GENE-081105-106	Length:	590	Species:	Danio rerio

Alignment Length:	556	Identity:	154/556 - (27%)
Similarity:	257/556 - (46%)	Gaps:	73/556 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LFLIIWSCG--TLAADILMATQGGTKSHKIPFWELAKGLISRGHNITFLSGFPADFNIEGLLEVT 69
            |...|||..  :||..||:....|  ||.:....|.:.|..|||.:|.:....:.:..|.....|
Zfish    68 LVAFIWSLPSLSLAGKILVYPVDG--SHWLNMNILLQELHQRGHKLTVVRSANSWYIPENATHYT 130

  Fly    70 PAGL-VEYIHNYTNWDLLGSRMAGEMPIKPWDGLRYAF-------------------ESCDAMLR 114
            ...: |.::.:..:...:.|.:...:.|:...|..::|                   |....:|.
Zfish   131 SITIQVNHLSSLEDPKYMASFLKRNIDIQRGKGSIWSFLALQKEIITLLEESHRSTAEMVRVVLE 195

  Fly   115 DSE-TKELTKKSFDLAILD-----GAFPECFLGLMYDFKIPFMYINTVGFYTGSISTAGNPVSYA 173
            |.: .|.|.:..:||.:.|     |.....:|||...|.:.:: .|..|.:    :.|.:|:||
Zfish   196 DEKLIKTLKESKYDLMLTDPGFAGGVILGAYLGLPMVFNVRWI-TNAEGHF----AIAPSPLSY- 254

  Fly   174 ITPNFYSRFTDTMNLYERAINTA-MQIGQTLMHMYVMRRTHLVMREHL--GTQIPHPYEMSRNVS 235
             .|...||.||.|:...:..|.. ..|||.:.||........|:.:::  .|.:   |.:.:...
Zfish   255 -IPTIGSRVTDKMSFANKLKNIMHFGIGQYIDHMLTRPLYQGVISKYIDPNTNV---YALIQGAD 315

  Fly   236 FILQNGHAVLSYPRAFNPNVAEVACIHCRPARKLPRNLEEFIGASGASGFIYVSMGSSVKAANMP 300
            ..|.....|..:||...|||..:....|:|::.||..|.:|:.:||..|.:.:|:| ::..:.:|
Zfish   316 LWLMRVDFVFEFPRPTMPNVVYIGGFQCKPSKPLPDELNKFVESSGEHGVVIMSLG-TLLGSLVP 379

  Fly   301 EALRHMLVKTFARLPYHVLWKYEGSSTDIKDITSNVKLSRWLPQQDILGHPKLRAFVTHGGLLSM 365
            : :..::...||:||..|:|::.|...  ..:.:|..:..||||.|:|||||.:|||||||...:
Zfish   380 D-ISEIVASAFAQLPQKVIWRHVGEKP--STLGNNTLVVDWLPQNDLLGHPKTKAFVTHGGTNGI 441

  Fly   366 FETVYHGVPVVTMPVFCDHDVNSAKAEVDGYAIKLDLQTLSANQLYKAIMKVIHNPR-YRNSARH 429
            :|.:|||||::.:|:..|...|..:.|..|.|..||:.||..:.|.:|:..::...: |:.:.|.
Zfish   442 YEAIYHGVPMLGLPLIFDQFDNIIRLEARGVARMLDVATLDVDILTQALKDILDEKQSYQKNMRK 506

  Fly   430 RQKLFLDQRSTALDTAIYWTEYVLRHNGAYHLQTPSRNMTWWQYYLLDVVAVYL-------ILLY 487
            ...|..|.....||:||:|.|:|:||.||.||:|.|..:.|:.|:.|||:|:.:       :||.
Zfish   507 MSSLHRDTPLKPLDSAIFWLEFVMRHKGAAHLRTESYKLPWYSYHCLDVLALIMSLCTAAGLLLI 571

  Fly   488 VLILALRRIDFPYEKVRSLYSLMAPFITIAKTKSKK 523
            ::..||.|                  ..:.|.|:||
Zfish   572 LISRALLR------------------ACVRKIKAKK 589

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt50B3	NP_001260710.1	YjiC	28..434	CDD:224732	114/435 (26%)
Ugt50B3	NP_001260710.1	egt	<172..479	CDD:223071	101/310 (33%)
ugt5e1	XP_005166829.1	UDPGT	82..586	CDD:278624	145/537 (27%)
ugt5e1	XP_005166829.1	egt	<324..550	CDD:223071	81/229 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.810