DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30429 and JPH4

DIOPT Version :9

Sequence 1:	NP_726512.1	Gene:	CG30429 / 246609	FlyBaseID:	FBgn0050429	Length:	305	Species:	Drosophila melanogaster
Sequence 2:	NP_001139500.1	Gene:	JPH4 / 84502	HGNCID:	20156	Length:	628	Species:	Homo sapiens

Alignment Length:	311	Identity:	62/311 - (19%)
Similarity:	90/311 - (28%)	Gaps:	162/311 - (52%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 FYYPGGGSYSGYWLCNKHQGWGVKKTAKRTCQYFYGKKHPEGQLIYEGDWV--MNKRQGVGSMLR 86
            |..|||.||.|:|...|.:|.||::.::.|               |.|:|:  :..|.||...:.
Human    53 FTGPGGHSYQGHWQQGKREGLGVERKSRWT---------------YRGEWLGGLKGRSGVWESVS 102

  Fly    87 KRGTEVQLIYSGRWYDDMKCGEGKQFYSDGCVYFGKWIKNRRHGLGIQW---YN----------- 137
                  .|.|:|.|.|..:.|.|.:.||||..|.|:|...:|||.|::.   |:
Human   103 ------GLRYAGLWKDGFQDGYGTETYSDGGTYQGQWQAGKRHGYGVRQSVPYHQAALLRSPRRT 161

  Fly   138 ------------------------------------------DG--------------------- 139
                                                      ||
Human   162 SLDSGHSDPPTPPPPLPLPGDEGGSPASGSRGGFVLAGPGDADGASSRKRTPAAGGFFRRSLLLS 226

  Fly   140 -----------------------------------------------------NIYAGEWETDFR 151
                                                                 .:|||||..|.|
Human   227 GLRAGGRRSSLGSKRGSLRSEVSSEVGSTGPPGSEASGPPAAAPPALIEGSATEVYAGEWRADRR 291

  Fly   152 HGLGVMFYANGNRYEGHFARGYKNGEGVFYHMHT----GQIQKGMWENDNL 198
            .|.||...:||.||||.:....::|.|     .|    |..::|.::.:.|
Human   292 SGFGVSQRSNGLRYEGEWLGNRRHGYG-----RTTRPDGSREEGKYKRNRL 337

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30429	NP_726512.1	COG4642	59..194	CDD:226989	48/270 (18%)
JPH4	NP_001139500.1	PLN03185	5..>143	CDD:215619	36/110 (33%)
		MORN 1	50..72		9/18 (50%)
		MORN 2	74..95		6/35 (17%)
		MORN 3	96..117		7/26 (27%)
		MORN 4	118..140		9/21 (43%)
		MORN 5	141..163		2/21 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	158..214		2/55 (4%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	231..276		0/44 (0%)
		PLN03185	281..>340	CDD:215619	22/62 (35%)
		MORN 7	317..339		5/26 (19%)
		MORN 8	340..362
		PRK07003	<369..>606	CDD:235906
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	415..602
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4642
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900