DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30429 and JPH1

DIOPT Version :9

Sequence 1:	NP_726512.1	Gene:	CG30429 / 246609	FlyBaseID:	FBgn0050429	Length:	305	Species:	Drosophila melanogaster
Sequence 2:	NP_001304759.1	Gene:	JPH1 / 56704	HGNCID:	14201	Length:	661	Species:	Homo sapiens

Alignment Length:	308	Identity:	57/308 - (18%)
Similarity:	87/308 - (28%)	Gaps:	156/308 - (50%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 FYYPGGGSYSGYWLCNKHQGWGVKKTAKRTCQYFYGKKHPEGQLIYEGDWV--MNKRQGVGSMLR 86
            :.:|.|.:|.|||...|..|.||:               .:|:.:|.|:|.  ...|.||...|.
Human    52 YTWPSGNTYQGYWAQGKRHGLGVE---------------TKGKWMYRGEWSHGFKGRYGVRQSLC 101

  Fly    87 KRGTEVQLIYSGRWYDDMKCGEGKQFYSDGCVYFGKWIKNRRHGLGIQ----------------- 134
            ....     |.|.|.:.::.|.|.:.|.||..|.|:|....|||.|::
Human   102 TPAR-----YEGTWSNGLQDGYGVETYGDGGTYQGQWAGGMRHGYGVRQSVPYGMATVIRSPLRT 161

  Fly   135 -----------------------------------WYNDGNI----------------------- 141
                                               ::.|..:
Human   162 SLASLRSEQSNGSVLHDAAAAADSPAGTRGGFVLNFHADAELAGKKKGGLFRRGSLLGSMKLRKS 226

  Fly   142 ------------------------------------------------------YAGEWETDFRH 152
                                                                  |.|||:.|.|:
Human   227 ESKSSISSKRSSVRSDAAMSRISSSDANSTISFGDVDCDFCPVEDHVDATTTETYMGEWKNDKRN 291

  Fly   153 GLGVMFYANGNRYEGHFARGYKNGEG--VFYHMHTGQIQKGMWENDNL 198
            |.||...:||.:|||.:|...::|.|  ||   ..|..::|.::|:.|
Human   292 GFGVSERSNGMKYEGEWANNKRHGYGCTVF---PDGSKEEGKYKNNIL 336

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30429	NP_726512.1	COG4642	59..194	CDD:226989	45/267 (17%)
JPH1	NP_001304759.1	PLN03185	4..>143	CDD:215619	32/110 (29%)
		MORN 1	14..36
		MORN 2	38..59		2/6 (33%)
		MORN 3	60..82		9/36 (25%)
		PLN03185	106..>325	CDD:215619	35/221 (16%)
		MORN 4	106..128		8/21 (38%)
		MORN 5	129..151		7/21 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	228..247		0/18 (0%)
		MORN 6	281..303		11/21 (52%)
		MORN 7	304..326		9/24 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	433..631
		TonB	<434..>528	CDD:223880
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4642
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900