DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG30429 and Als2

DIOPT Version :9

Sequence 1:	NP_726512.1	Gene:	CG30429 / 246609	FlyBaseID:	FBgn0050429	Length:	305	Species:	Drosophila melanogaster
Sequence 2:	NP_649347.1	Gene:	Als2 / 40410	FlyBaseID:	FBgn0037116	Length:	1486	Species:	Drosophila melanogaster

Alignment Length:	333	Identity:	73/333 - (21%)
Similarity:	112/333 - (33%)	Gaps:	102/333 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 CSSGRRATFY------YPGGGSYSGYWLCNKHQGWGVKKTAKRTCQY--------FYG------- 59
            |.:.|:...:      ||.|..|.|.......:|:| |.....|..|        |:|
  Fly   744 CGTWRKGVLHGNCYLEYPDGSVYCGELQHGIIEGFG-KMVIPTTGLYVGNFKGGRFHGHGVYEMH 807

  Fly    60 -KKHPEGQLIYEGDWVMNKRQGVGSMLRKRGTEVQLIYSGRWYDDMKCGEGK-QFYSDGCVYFGK 122
             |..||.: :|||::......|.|.|...|     .||.|.:..:.:.|.|. :....|..|.|.
  Fly   808 CKDSPESE-VYEGNFCEGLFHGHGVMRNNR-----YIYVGEYQANARSGYGVIEDLVSGDKYMGM 866

  Fly   123 WIKNRRHGLGIQWYNDGNIYAGEWETDFRHGLGVMFYANGNRYEGHFARGYKNGEGVFY------ 181
            :..|:|.|:|....|.|:.:.|.:..|...|.||..:.|...|||.......||.|.:|
  Fly   867 FADNKRSGIGSCITNRGDYFEGSFSGDDLTGSGVAVFENDYYYEGELTLLGPNGRGEYYMPSGDA 931

  Fly   182 -----HMHTGQIQ--------------KGMWENDNLKTSVVQDEPKIRCNAVITSYPIPRNYLKY 227
                 .|.||:..              .|.|           |..:|:...::    :.|.:.||
  Fly   932 CGGSGAMGTGEFDDTCELIGNKMFGQLSGTW-----------DTVRIQAGELV----LNRRFPKY 981

  Fly   228 PNEIMRDLFQRHKDFSNKPHRRFNDRVSLAFIHHHRQYASCEERFASPTIVDLYPRAEFGCTCDC 292
            |:.:.|.:                       :.|:|::.|....|.|    ||     ..||...
  Fly   982 PSSLGRQV-----------------------VDHNRKWRSLFNNFES----DL-----ANCTAST 1014

  Fly   293 ENVARNET 300
            .:...|::
  Fly  1015 SSSGGNQS 1022

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30429	NP_726512.1	COG4642	59..194	CDD:226989	42/168 (25%)
Als2	NP_649347.1	RCC1	258..304	CDD:278826
		RCC1_2	292..321	CDD:290274
		RCC1	308..361	CDD:278826
		PH-like	616..715	CDD:302622
		VPS9	1373..1479	CDD:280383
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4642
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900