DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG30424 and Cgas

DIOPT Version :9

Sequence 1:NP_001097455.1 Gene:CG30424 / 246606 FlyBaseID:FBgn0050424 Length:389 Species:Drosophila melanogaster
Sequence 2:NP_775562.2 Gene:Cgas / 214763 MGIID:2442261 Length:507 Species:Mus musculus


Alignment Length:326 Identity:74/326 - (22%)
Similarity:124/326 - (38%) Gaps:110/326 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 LKIAKPNEFDLVFKLKFP------YYKSIA--VTRDPKIP-GNVL--------LDMTRVLELLKD 49
            :||:.|||||::|||:.|      ||::.|  :.:..:|| ||.|        |..|::|...:.
Mouse   204 VKISAPNEFDVMFKLEVPRIELQEYYETGAFYLVKFKRIPRGNPLSHFLEGEVLSATKMLSKFRK 268

  Fly    50 DPREDFQRIRELIQGRLVDAQNFFVVDRLRSWLQSLFSQALNRISYRVELVAGVVSHLKYRTCGP 114
            ..:|:.:.|::              :|                           ||..|.:...|
Mouse   269 IIKEEVKEIKD--------------ID---------------------------VSVEKEKPGSP 292

  Fly   115 AHTIYVYGDYEYSVDYVPAICLAAE---------------QNVLPTKQLECFKRANTSYWEAIPK 164
            |.|:.:....|.|||    |.||.|               |..|.||.....:|   ..:..:||
Mouse   293 AVTLLIRNPEEISVD----IILALESKGSWPISTKEGLPIQGWLGTKVRTNLRR---EPFYLVPK 350

  Fly   165 PLKPLTETSMISFRSSFYAVEKILLQD--VHENC----------RNAIRFM--------KKFRDV 209
            ..|........::|.||...||.:|.:  :.:.|          :..::.|        |:|:::
Mouse   351 NAKDGNSFQGETWRLSFSHTEKYILNNHGIEKTCCESSGAKCCRKECLKLMKYLLEQLKKEFQEL 415

  Fly   210 KTNLGNCKSYYIKTLFLWKIIQEPESYWLNPLSFILADMFDDL----AENLRRGVITFFWDPELN 270
            .   ..| ||::||.......|:|:....:|.:  |:..||.|    .|.||...:..::.|:.|
Mouse   416 D---AFC-SYHVKTAIFHMWTQDPQDSQWDPRN--LSSCFDKLLAFFLECLRTEKLDHYFIPKFN 474

  Fly   271 M 271
            :
Mouse   475 L 475

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG30424NP_001097455.1 Mab-21 1..289 CDD:281298 74/326 (23%)
CgasNP_775562.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..151
DNA-binding. /evidence=ECO:0000269|PubMed:28363908 1..146
PHA03247 <3..142 CDD:223021
Required for association with the cell membrane. /evidence=ECO:0000250|UniProtKB:Q8N884 48..59
Required for activation upon DNA viral infection. /evidence=ECO:0000269|PubMed:28314590 119..132
DNA-binding. /evidence=ECO:0000269|PubMed:23647843, ECO:0000269|PubMed:28902841, ECO:0000269|PubMed:28963528, ECO:0007744|PDB:5N6I 158..201
Mab-21 200..495 CDD:397398 74/326 (23%)
Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:Q8N884 281..291 4/36 (11%)
DNA-binding. /evidence=ECO:0000269|PubMed:23647843, ECO:0000269|PubMed:28902841, ECO:0000269|PubMed:28963528, ECO:0007744|PDB:5N6I 372..395 3/22 (14%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167838667
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR10656
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
22.030

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