DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30424 and CGAS

DIOPT Version :9

Sequence 1:	NP_001097455.1	Gene:	CG30424 / 246606	FlyBaseID:	FBgn0050424	Length:	389	Species:	Drosophila melanogaster
Sequence 2:	NP_612450.2	Gene:	CGAS / 115004	HGNCID:	21367	Length:	522	Species:	Homo sapiens

Alignment Length:	368	Identity:	84/368 - (22%)
Similarity:	138/368 - (37%)	Gaps:	120/368 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LKIAKPNEFDLVFKLKFP------------YYKSIAVTRDPKIPGNVLLDMTRVLELLKDDPRED 54
            :||:.|||||::|||:.|            || .:...|:|                 |::|...
Human   218 VKISAPNEFDVMFKLEVPRIQLEEYSNTRAYY-FVKFKRNP-----------------KENPLSQ 264

  Fly    55 FQRIRELIQGRLVDAQNFFVVDRLRSWLQSLFSQALNRISYRVELVAGVVSHLKYRTCGPAHTIY 119
            |      ::|.::.|      .::.|..:.:..:.:|.|.     ...|:...| |...||.|:.
Human   265 F------LEGEILSA------SKMLSKFRKIIKEEINDIK-----DTDVIMKRK-RGGSPAVTLL 311

  Fly   120 VYGDYEYSVDYVPAICLAAE---------------QNVLPTKQLECFKRANTSYWEAIPKPLKPL 169
            :  ..:.|||    |.||.|               ||.|..|   ..|:.....:..:||..|..
Human   312 I--SEKISVD----ITLALESKSSWPASTQEGLRIQNWLSAK---VRKQLRLKPFYLVPKHAKEG 367

  Fly   170 TETSMISFRSSFYAVEKILL----------QDVHENC--RNAIRFMK--------KFRDVKTNLG 214
            ......::|.||..:||.:|          ::..|.|  ::.::.||        :|:| |.:|.
Human   368 NGFQEETWRLSFSHIEKEILNNHGKSKTCCENKEEKCCRKDCLKLMKYLLEQLKERFKD-KKHLD 431

  Fly   215 NCKSYYIKTLFLWKIIQEP-ESYW---------LNPLSFILADMFDDLAENLRRGVITFFWDPEL 269
            ...||::||.|.....|.| :|.|         .|.:::.|..:..:..||        ::.||.
Human   432 KFSSYHVKTAFFHVCTQNPQDSQWDRKDLGLCFDNCVTYFLQCLRTEKLEN--------YFIPEF 488

  Fly   270 NMIDALTRDQVWEMYLCVQRIPRDLRGAEISRNKWSFFVLREF 312
            |:..:...|:..:.:|..|        .|..||. .|.|..||
Human   489 NLFSSNLIDKRSKEFLTKQ--------IEYERNN-EFPVFDEF 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30424	NP_001097455.1	Mab-21	1..289	CDD:281298	76/343 (22%)
CGAS	NP_612450.2	DNA-binding. /evidence=ECO:0000269\|PubMed:28363908	1..160
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..144
		RecX	15..>117	CDD:294607
		Required for association with the cell membrane. /evidence=ECO:0000269\|PubMed:30827685	64..75
		Required for activation upon DNA viral infection. /evidence=ECO:0000269\|PubMed:28314590	120..160
		DNA-binding. /evidence=ECO:0000269\|PubMed:30007416, ECO:0000305\|PubMed:23707061, ECO:0007744\|PDB:6CTA	173..215
		Mab-21	214..510	CDD:281298	77/353 (22%)
		Nuclear localization signal. /evidence=ECO:0000269\|PubMed:30356214	295..305		3/10 (30%)
		DNA-binding. /evidence=ECO:0000305\|PubMed:23707061	384..407		4/22 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148567
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D331478at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10656
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.040