DRSC/TRiP Functional Genomics Resources

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Protein Alignment tbrd-3 and BRDT

DIOPT Version :9

Sequence 1:NP_726307.1 Gene:tbrd-3 / 246604 FlyBaseID:FBgn0050417 Length:268 Species:Drosophila melanogaster
Sequence 2:NP_001229735.2 Gene:BRDT / 676 HGNCID:1105 Length:951 Species:Homo sapiens


Alignment Length:315 Identity:81/315 - (25%)
Similarity:129/315 - (40%) Gaps:74/315 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 ETERSSPEINACKVIIKRLFSSTYKNIAWVFYEPLDPQLLGLHDYHEIVREPMDLSTVRHRLNTG 70
            :|.:.:.::..|..|:|.:.:..:.:.||.||.|:|...||||:|:::|:.||||.|::.:::..
Human   269 KTVKVTEQLRHCSEILKEMLAKKHFSYAWPFYNPVDVNALGLHNYYDVVKNPMDLGTIKEKMDNQ 333

  Fly    71 CYLSAADFAKDIRLIFYNTYLYTNPDHLCYHMAKQLQIIFEEMYSQVQL---------YICSSGS 126
            .|..|..||.|:||:|.|.|.|..|||....||:.||.:||..:|::.:         ||.:..:
Human   334 EYKDAYKFAADVRLMFMNCYKYNPPDHEVVTMARMLQDVFETHFSKIPIEPVESMPLCYIKTDIT 398

  Fly   127 KVRAEE---ESSSDESDSSSPEDE----------------------------------------- 147
            :....|   |:||:.:.|...|||                                         
Human   399 ETTGRENTNEASSEGNSSDDSEDERVKRLAKLQEQLKAVHQQLQVLSQVPFRKLNKKKEKSKKEK 463

  Fly   148 ----VNGSEVSPSIMGAPPSCTPTTECTPTPDWTPP--------ATLETSEQQEPFTTEEDLDLH 200
                ||.|..:|..|     |........:....|.        ...|..:..:|...:|...|.
Human   464 KKEKVNNSNENPRKM-----CEQMRLKEKSKRNQPKKRKQQFIGLKSEDEDNAKPMNYDEKRQLS 523

  Fly   201 AKIQQLDGEVLLHVIHFIQRMEGAEYCNK---ELEFDICKLKVHTKRGIRDYLAS 252
            ..|.:|.|:.|..|:|.||..| ....|.   |:|.|...||..|.|.:..|:::
Human   524 LNINKLPGDKLGRVVHIIQSRE-PSLSNSNPDEIEIDFETLKASTLRELEKYVSA 577

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tbrd-3NP_726307.1 Bromo_Brdt_II_like 13..114 CDD:99930 40/100 (40%)
BRDTNP_001229735.2 Bromo_Brdt_I_like 27..133 CDD:99929
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 206..232
Nuclear localization signal. /evidence=ECO:0000269|PubMed:22971749 213..224
Bromo_Brdt_II_like 276..377 CDD:99930 40/100 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 399..424 8/24 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 448..515 9/71 (13%)
BET 513..575 CDD:293640 20/62 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 614..702
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 886..928
BRD4_CDT 909..951 CDD:293710
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5076
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000322
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR22880
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X197
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
54.910

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