DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tbrd-3 and crebbpa

DIOPT Version :9

Sequence 1:	NP_726307.1	Gene:	tbrd-3 / 246604	FlyBaseID:	FBgn0050417	Length:	268	Species:	Drosophila melanogaster
Sequence 2:	XP_005161826.1	Gene:	crebbpa / 566841	ZFINID:	ZDB-GENE-050208-439	Length:	2350	Species:	Danio rerio

Alignment Length:	299	Identity:	68/299 - (22%)
Similarity:	114/299 - (38%)	Gaps:	78/299 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 TERSSPEINACKVI----IKRLFSSTYKNI------AWVFYEPLDPQLLGLHDYHEIVREPMDLS 61
            |..|||..:..|:.    :::....|.:::      :..|.:|:||.|||:.||.:||:.|:|||
Zfish   965 TASSSPSQSRRKIFKPEELRQALMPTLESLYRQDPESLPFRQPVDPILLGIPDYFDIVKNPIDLS 1029

  Fly    62 TVRHRLNTGCYLSAADFAKDIRLIFYNTYLYTNPDHLCYHMAKQLQIIFEEMYSQVQL---YICS 123
            |::.:|:||.|.....:..|:.|:|.|.:||.......|....:|..:||:....|..   |.|.
Zfish  1030 TIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKYCSKLAEVFEQEIDPVMQGLGYCCG 1094

  Fly   124 SGSKVRAEEESSSDESDSSSPED------------------EVNGSEVSPSIMGAPPSCTPTTEC 170
            ...:...:......:...:.|.|                  |:.|..|:   :|..|:
Zfish  1095 RKYEFSPQTLCCYGKQLCTIPRDGTYYSYQNRYHFCEKCFNEIQGDSVT---LGDDPA------- 1149

  Fly   171 TPTPDWTPPATLETSEQ----------QEPFTTEEDLDLHAKIQQLDGEVLLHVIHFIQRMEGAE 225
                   .|.|:.:.:|          .|||.  |..|...|:.|      :.|:|:........
Zfish  1150 -------QPQTMISKDQFERKKNDTLDPEPFV--ECKDCGRKMHQ------ICVLHYEVIWPSGF 1199

  Fly   226 YCNKELEFDICKLKVHTKRGIRDYLASKGFTGKRVARTK 264
            .|      |.|     .|:..:....:| ||.||:..|:
Zfish  1200 IC------DNC-----LKKSAKSRKENK-FTAKRLQSTR 1226

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tbrd-3	NP_726307.1	Bromo_Brdt_II_like	13..114	CDD:99930	32/110 (29%)
crebbpa	XP_005161826.1	zf-TAZ	325..392	CDD:280324
		KIX	548..628	CDD:280354
		PHA03193	<751..919	CDD:177555
		Bromo_cbp_like	980..1087	CDD:99927	32/106 (30%)
		RING_CBP-p300	1099..1171	CDD:276805	10/88 (11%)
		PHD_CBP	1172..1206	CDD:277117	11/52 (21%)
		HAT_KAT11	1235..1542	CDD:285432
		ZZ_CBP	1598..1638	CDD:239077
		ZnF_TAZ	1659..1737	CDD:214717
		Med15	1902..>2333	CDD:255446
		Creb_binding	1957..2043	CDD:286163
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000