DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tbrd-3 and BRD4

DIOPT Version :9

Sequence 1:	NP_726307.1	Gene:	tbrd-3 / 246604	FlyBaseID:	FBgn0050417	Length:	268	Species:	Drosophila melanogaster
Sequence 2:	NP_001366220.1	Gene:	BRD4 / 23476	HGNCID:	13575	Length:	1362	Species:	Homo sapiens

Alignment Length:	332	Identity:	94/332 - (28%)
Similarity:	140/332 - (42%)	Gaps:	83/332 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 AKQETERSSPEINACKVIIKRLFSSTYKNIAWVFYEPLDPQLLGLHDYHEIVREPMDLSTVRHRL 67
            |.:::.:.|.::..|..|:|.:|:..:...||.||:|:|.:.||||||.:|::.|||:||::.:|
Human   343 APEKSSKVSEQLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKL 407

  Fly    68 NTGCYLSAADFAKDIRLIFYNTYLYTNPDHLCYHMAKQLQIIFEEMYSQV------QLYICSS-- 124
            ....|..|.:|..|:||:|.|.|.|..|||....||::||.:||..::::      .:...||
Human   408 EAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEPEEPVVAVSSPA 472

  Fly   125 ---GSKVRAEEESSSDESDSSSPED---------------------------------------- 146
               .:||.|...||...|||||..|
Human   473 VPPPTKVVAPPSSSDSSSDSSSDSDSSTDDSEEERAQRLAELQEQLKAVHEQLAALSQPQQNKPK 537

  Fly   147 ------------------EVNGSEVSPSIMGAPPSCTPTTECT--------PTP-DWTPPATLET 184
                              ||..::.|.: ...||..|.....:        |.| ...||.|.|:
Human   538 KKEKDKKEKKKEKHKRKEEVEENKKSKA-KEPPPKKTKKNNSSNSNVSKKEPAPMKSKPPPTYES 601

  Fly   185 SEQQ--EPFTTEEDLDLHAKIQQLDGEVLLHVIHFIQRME-GAEYCN-KELEFDICKLKVHTKRG 245
            .|:.  :|.:.||...|...|.:|.||.|..|:|.||..| ..:..| .|:|.|...||..|.|.
Human   602 EEEDKCKPMSYEEKRQLSLDINKLPGEKLGRVVHIIQSREPSLKNSNPDEIEIDFETLKPSTLRE 666

  Fly   246 IRDYLAS 252
            :..|:.|
Human   667 LERYVTS 673

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tbrd-3	NP_726307.1	Bromo_Brdt_II_like	13..114	CDD:99930	42/100 (42%)
BRD4	NP_001366220.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..58
		Bromo_Brdt_I_like	58..164	CDD:99929
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	174..229
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	242..352		1/8 (13%)
		Bromo_Brdt_II_like	353..454	CDD:99930	42/100 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	463..615		28/152 (18%)
		NPS region	484..503		8/18 (44%)
		BID region	524..579		6/55 (11%)
		BET	609..673	CDD:407211	23/63 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	674..1100		94/332 (28%)
		PRK03427	<809..>922	CDD:235124
		C-terminal (CTD) region	1047..1362
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1116..1339
		BRD4_CDT	1319..1362	CDD:407248
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000322
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22880
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X197
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.910