DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tbrd-3 and Crebbp

DIOPT Version :9

Sequence 1:	NP_726307.1	Gene:	tbrd-3 / 246604	FlyBaseID:	FBgn0050417	Length:	268	Species:	Drosophila melanogaster
Sequence 2:	XP_006521814.1	Gene:	Crebbp / 12914	MGIID:	1098280	Length:	2451	Species:	Mus musculus

Alignment Length:	314	Identity:	74/314 - (23%)
Similarity:	116/314 - (36%)	Gaps:	81/314 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 AKQETERSS-------------------PE--INACKVIIKRLFSSTYKNIAWVFYEPLDPQLLG 46
            ||:|.|.||                   ||  ..|....::.|:....:::.  |.:|:||||||
Mouse  1060 AKEEEENSSNDTASQSTSPSQPRKKIFKPEELRQALMPTLEALYRQDPESLP--FRQPVDPQLLG 1122

  Fly    47 LHDYHEIVREPMDLSTVRHRLNTGCYLSAADFAKDIRLIFYNTYLYTNPDHLCYHMAKQLQIIFE 111
            :.||.:||:.||||||::.:|:||.|.....:..|:.|:|.|.:||.......|....:|..:||
Mouse  1123 IPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFE 1187

  Fly   112 EMYSQV----------------QLYICSSGSKVRAEEESSSDESDSSSPE--------------- 145
            :....|                |...|..........:::.....:|||:
Mouse  1188 QEIDPVMQSLGYCCGRKYEFSPQTLCCYGKQLCTIPRDAAYYSYQNSSPKYGLLADRYHFCEKCF 1252

  Fly   146 DEVNGSEVSPSIMGAPPSCTPTTECTPTPDWTPPATLETSEQQEPFTTEEDLDLHAKIQQLDGEV 210
            .|:.|..|:   :|..||...||......:.....||:    .|||.  :..:...|:.|
Mouse  1253 TEIQGENVT---LGDDPSQPQTTISKDQFEKKKNDTLD----PEPFV--DCKECGRKMHQ----- 1303

  Fly   211 LLHVIHFIQRMEGAEYCNKELEFDICKLKVHTKRGIRDYLASKGFTGKRVARTK 264
             :.|:|:.........|      |.|..|....|      ....|:.||:..|:
Mouse  1304 -ICVLHYDIIWPSGFVC------DNCLKKTGRPR------KENKFSAKRLQTTR 1344

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tbrd-3	NP_726307.1	Bromo_Brdt_II_like	13..114	CDD:99930	35/102 (34%)
Crebbp	XP_006521814.1	zf-TAZ	362..429	CDD:366931
		KIX	586..666	CDD:366953
		PHA03247	<687..1037	CDD:223021
		COG5076	942..>1194	CDD:227408	42/135 (31%)
		Bromo_cbp_like	1088..1195	CDD:99927	37/108 (34%)
		RING_CBP-p300	1207..1289	CDD:276805	15/88 (17%)
		PHD_CBP_p300	1291..1322	CDD:277032	7/44 (16%)
		HAT_KAT11	1353..>1564	CDD:369758
		ZZ_CBP	1716..1756	CDD:239077
		ZnF_TAZ	1777..1855	CDD:214717
		Med15	1971..>2422	CDD:312941
		Creb_binding	2045..2125	CDD:370251
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900