DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tbrd-3 and Brdt

DIOPT Version :9

Sequence 1:	NP_726307.1	Gene:	tbrd-3 / 246604	FlyBaseID:	FBgn0050417	Length:	268	Species:	Drosophila melanogaster
Sequence 2:	XP_006534791.1	Gene:	Brdt / 114642	MGIID:	1891374	Length:	961	Species:	Mus musculus

Alignment Length:	324	Identity:	83/324 - (25%)
Similarity:	138/324 - (42%)	Gaps:	65/324 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ETERSSPEINACKVIIKRLFSSTYKNIAWVFYEPLDPQLLGLHDYHEIVREPMDLSTVRHRLNTG 70
            :|.:.:.::..|..|:|.:.:..:...||.||.|:|...||||:|:::|:.||||.|::.:::..
Mouse   264 KTVKVTEQLKHCSEILKEMLAKKHLPYAWPFYNPVDADALGLHNYYDVVKNPMDLGTIKGKMDNQ 328

  Fly    71 CYLSAADFAKDIRLIFYNTYLYTNPDHLCYHMAKQLQIIFEEMYSQV------QLYIC--SSGSK 127
            .|..|.:||.|:||:|.|.|.|..|||....||:.||.:||..::::      .::.|  ::.|.
Mouse   329 EYKDAYEFAADVRLMFMNCYKYNPPDHEVVAMARTLQDVFELHFAKIPDEPIESMHACHLTTNSA 393

  Fly   128 VRAEEESSSDES--DSSSPEDE-------------VNGSEVSPSIMGAPP-----------SCTP 166
            .....||||:.|  |:||.:.|             :|.......::...|           ...|
Mouse   394 QALSRESSSEASSGDASSEDSEDERVQHLAKLQEQLNAVHQQLQVLSQVPLRKLKKKNEKSKRAP 458

  Fly   167 TTECTPTPDWTPPATLETSEQQE-----------------------PFTTEEDLDLHAKIQQLDG 208
            ..:.....|..|....:..:|:|                       |...:|...|...|.:|.|
Mouse   459 KRKKVNNRDENPRKKPKQMKQKEKAKINQPKKKKPLLKSEEEDNAKPMNYDEKRQLSLDINKLPG 523

  Fly   209 EVLLHVIHFIQRMEGAEYCNK--ELEFDICKLKVHTKRGIRDYL------ASKGFTGKRVARTK 264
            :.|..::|.||..|.:...:.  |:|.|...||..|.|.:..|:      .|.....|:|.|:|
Mouse   524 DKLGRIVHIIQSREPSLRNSNPDEIEIDFETLKASTLRELEKYVLACLRKRSLKPQAKKVVRSK 587

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tbrd-3	NP_726307.1	Bromo_Brdt_II_like	13..114	CDD:99930	40/100 (40%)
Brdt	XP_006534791.1	Bromo_Brdt_I_like	26..132	CDD:99929
		Bromo_Brdt_II_like	271..372	CDD:99930	40/100 (40%)
		BET	505..567	CDD:374956	18/61 (30%)
		BRD4_CDT	919..961	CDD:374989
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000322
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22880
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X197
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.910