DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GstE9 and MARS1

DIOPT Version :9

Sequence 1:	NP_725784.1	Gene:	GstE9 / 246581	FlyBaseID:	FBgn0063491	Length:	221	Species:	Drosophila melanogaster
Sequence 2:	NP_004981.2	Gene:	MARS1 / 4141	HGNCID:	6898	Length:	900	Species:	Homo sapiens

Alignment Length:	158	Identity:	34/158 - (21%)
Similarity:	67/158 - (42%)	Gaps:	31/158 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 LKNPQHTVPVLE-DDGKFIWESHAICAY--LVRRYAKSDDLYPKDYFKRALVDQRLHFESGVLFQ 109
            |..|:  ||||: |.|.:::.:.|||.|  |:..:.:.|           |.:|.|.:|:..|..
Human    43 LTRPK--VPVLQLDSGNYLFSTSAICRYFFLLSGWEQDD-----------LTNQWLEWEATELQP 94

  Fly   110 GCIRNIAIPLFY-----KNITEVPRSQIDAIYEAYDFLEAFIGNQ--AYLCGPVITIADYSVVSS 167
            .    ::..|:|     |...:|    :.::..|...::..:..|  .:|.|...::||..:..:
Human    95 A----LSAALYYLVVQGKKGEDV----LGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGA 151

  Fly   168 VSSLVGLAAIDAKRYPKLNGWLDRMAAQ 195
            :..|:...|...:....|:.|...::.|
Human   152 LYPLLQDPAYLPEELSALHSWFQTLSTQ 179

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GstE9	NP_725784.1	GstA	4..201	CDD:223698	34/158 (22%)
		GST_N_Delta_Epsilon	4..76	CDD:239343	12/30 (40%)
		GST_C_Delta_Epsilon	92..209	CDD:198287	20/111 (18%)
MARS1	NP_004981.2	Thioredoxin_like	<27..68	CDD:294274	11/26 (42%)
		GstA	<47..189	CDD:223698	32/154 (21%)
		GST_C_MetRS_N	77..179	CDD:198340	20/120 (17%)
		PRK12268	264..819	CDD:237029
		MetRS_core	265..633	CDD:173907
		'HIGH' region	273..283
		'KMSKS' region	593..597
		Anticodon_Ia_Met	642..771	CDD:153411
		MetRS_RNA	845..889	CDD:238475
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0625
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810