DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30375 and Tmprss7

DIOPT Version :9

Sequence 1:	NP_724665.1	Gene:	CG30375 / 246575	FlyBaseID:	FBgn0050375	Length:	398	Species:	Drosophila melanogaster
Sequence 2:	NP_766043.3	Gene:	Tmprss7 / 208171	MGIID:	2686594	Length:	829	Species:	Mus musculus

Alignment Length:	441	Identity:	115/441 - (26%)
Similarity:	174/441 - (39%)	Gaps:	117/441 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LLYISLSCAQQQCTRFFD--LIPNRTINITSFNYPGAIPSGS-NCRFRLKAPSNHVIYLSC---- 69
            |::|.|.|:    :|..|  |:    :....:|.....|:|| .|...|..|...    .|
Mouse   441 LVHIQLQCS----SRLSDKPLL----VEYGGYNISQPCPAGSFRCSSGLCVPQAQ----RCDGVN 493

  Fly    70 -----RFELFPDT----CGSEFLFISRDGDLQFR-------DGERYCRMGQVNRISNFQTMAFAY 118
                 ..|||..|    |.|.          .||       ||.|.|..||..:...
Mouse   494 DCFDESDELFCVTVKPACNSS----------SFRQHGPLVCDGFRDCEDGQDEQNCT-------- 540

  Fly   119 YSSSPQTQQRSRLNCQAVARP--APCD-------------CGW----SFPNRIANGVEAGKHEFP 164
             .|.|.|.:..:.......|.  |.||             ||.    ||.:||..|.::.:..:|
Mouse   541 -RSIPCTSRTFKCGNDICFRKQNAQCDGIVDCPDGSDEEGCGCSRSSSFLHRIVGGSDSQEGTWP 604

  Fly   165 SMVGLRDLSSNLPIFCGGSIVSERYIMTAAHC------TARQPVASRL-LALVGEHDLSTGAESI 222
            ..|.|..:.|   .:||.|::|..::::||||      :...|..:.| :.:.|.....:....|
Mouse   605 WQVSLHFVGS---AYCGASVISREWLLSAAHCFHGNRLSDPTPWTAHLGMYVQGNAKFISPVRRI 666

  Fly   223 YAAQYRIQNIINHPGYMETASGNINDIALLQTATPIEW----SRGVAPICLP-----IRQAENSF 278
            ...:|......::            ||||||.:  |.|    .:.:.|||:|     :|..|..:
Mouse   667 VVHEYYNSQTFDY------------DIALLQLS--IAWPETLKQLIQPICIPPAGQKVRSGEKCW 717

  Fly   279 NYQNVDIMGWGTLGFAASK-SNTLQKATLLTMDNAVCRSRFNSSITPSHLCTYDAGGRGQDSCQY 342
                  :.|||....|.|| |..||:|.:..:|..||.|.: ..||...||.....|: .|:|:.
Mouse   718 ------VTGWGRRHEADSKGSPVLQQAEVELIDQTVCVSTY-GIITSRMLCAGVMSGK-SDACKG 774

  Fly   343 DSGGPVILRQRE--RMFQLGVISYGRACGQPFGIGVNTRVTSHLNWLWRYI 391
            |||||:..|::.  :....|::|:|..||:|...||.|||:|.:.|:.:|:
Mouse   775 DSGGPLSCRRKSDGKWILTGIVSWGHGCGRPNFPGVYTRVSSFVPWIHKYV 825

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30375	NP_724665.1	CUB	38..>100	CDD:294042	19/82 (23%)
		Tryp_SPc	151..386	CDD:214473	73/253 (29%)
		Tryp_SPc	152..387	CDD:238113	72/253 (28%)
Tmprss7	NP_766043.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	26..52
		SEA	94..194	CDD:366610
		CUB	<257..345	CDD:238001
		LDLa	470..504	CDD:238060	9/37 (24%)
		LDLa	545..580	CDD:238060	5/34 (15%)
		Tryp_SPc	591..821	CDD:214473	73/254 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	143	1.000	Inparanoid score	I4434
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.050