DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30375 and TMPRSS6

DIOPT Version :9

Sequence 1:	NP_724665.1	Gene:	CG30375 / 246575	FlyBaseID:	FBgn0050375	Length:	398	Species:	Drosophila melanogaster
Sequence 2:	NP_001275929.1	Gene:	TMPRSS6 / 164656	HGNCID:	16517	Length:	824	Species:	Homo sapiens

Alignment Length:	483	Identity:	124/483 - (25%)
Similarity:	183/483 - (37%)	Gaps:	153/483 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LSCAQQQCTRFFDLIPNR-----------------------TINITSFNYPGAIPSGSNCRFRLK 58
            |.|.|.|.|     |.||                       |||.||             :..|.
Human   386 LPCTQGQWT-----IQNRRLCGLRILQPYAERIPVVATAGITINFTS-------------QISLT 432

  Fly    59 APSNHVIYLSCRFELF--PDTCGSEFLFISRDGDLQFRDGERYCRMGQVNR----ISNFQTMAFA 117
            .|...|.|     .|:  .|.|..|||.......:...||.:.|..|...|    .:.||....:
Human   433 GPGVRVHY-----GLYNQSDPCPGEFLCSVNGLCVPACDGVKDCPNGLDERNCVCRATFQCKEDS 492

  Fly   118 YYSSSPQT--QQRSRLN------CQ----------------AVARPAP----------------C 142
            ...|.|:.  .|...||      ||                .|.:|.|                |
Human   493 TCISLPKVCDGQPDCLNGSDEEQCQEGVPCGTFTFQCEDRSCVKKPNPQCDGRPDCRDGSDEEHC 557

  Fly   143 DCGWSFP-NRIANGVEAGKHEFPSMVGLRDLSSNLPIFCGGSIVSERYIMTAAHCTARQPVASRL 206
            |||...| :||..|..:.:.|:|....|:....::   |||:::::|:::|||||.....:||.:
Human   558 DCGLQGPSSRIVGGAVSSEGEWPWQASLQVRGRHI---CGGALIADRWVITAAHCFQEDSMASTV 619

  Fly   207 LALV------------GEHDLSTGAESIYAAQYRIQNIINHPGYMETASGNINDIALLQTATPIE 259
            |..|            ||            ..:::..::.|| |.|..|.:. |:||||...|:.
Human   620 LWTVFLGKVWQNSRWPGE------------VSFKVSRLLLHP-YHEEDSHDY-DVALLQLDHPVV 670

  Fly   260 WSRGVAPICLPIRQAENSFNYQ---NVDIMGWGTLGFAASK----------------------SN 299
            .|..|.|:|||.|    |..::   :..|.|||.|...|.:                      ||
Human   671 RSAAVRPVCLPAR----SHFFEPGLHCWITGWGALREGALRADAVALFYGWRNQGSETCCCPISN 731

  Fly   300 TLQKATLLTMDNAVCRSRFNSSITPSHLCTYDAGGRGQDSCQYDSGGPVILRQRE-RMFQLGVIS 363
            .|||..:..:...:|...:...:||..||.....|: :|:||.|||||::.:... |.|..|::|
Human   732 ALQKVDVQLIPQDLCSEVYRYQVTPRMLCAGYRKGK-KDACQGDSGGPLVCKALSGRWFLAGLVS 795

  Fly   364 YGRACGQPFGIGVNTRVTSHLNWLWRYI 391
            :|..||:|...||.||:|..::|:.:.:
Human   796 WGLGCGRPNYFGVYTRITGVISWIQQVV 823

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30375	NP_724665.1	CUB	38..>100	CDD:294042	14/63 (22%)
		Tryp_SPc	151..386	CDD:214473	78/272 (29%)
		Tryp_SPc	152..387	CDD:238113	77/272 (28%)
TMPRSS6	NP_001275929.1	SEA	77..177	CDD:307516
		CUB	326..440	CDD:238001	16/71 (23%)
		LDLa	450..480	CDD:238060	8/29 (28%)
		LDLa	486..516	CDD:238060	7/29 (24%)
		Ldl_recept_a	520..557	CDD:278486	3/36 (8%)
		Tryp_SPc	568..822	CDD:238113	78/275 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	148	1.000	Inparanoid score	I4403
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.050