DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30375 and St14

DIOPT Version :9

Sequence 1:	NP_724665.1	Gene:	CG30375 / 246575	FlyBaseID:	FBgn0050375	Length:	398	Species:	Drosophila melanogaster
Sequence 2:	NP_446087.1	Gene:	St14 / 114093	RGDID:	69288	Length:	855	Species:	Rattus norvegicus

Alignment Length:	512	Identity:	119/512 - (23%)
Similarity:	186/512 - (36%)	Gaps:	175/512 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 YPGAIPSGSNCRFRLKAPSNHVIYLSCRFELF----PDT-----------------CG--SEF-- 82
            |||..|...||.:.:|.|:|..:  ..||:||    |:.                 ||  |:|
  Rat   356 YPGHYPPNINCTWNIKVPNNRNV--KVRFKLFYLVDPNIPVGSCTKDYVEINGEKFCGERSQFVV 418

  Fly    83 -------------------------------------LFISRDG-----DLQFRDG--------- 96
                                                 :|:.:.|     ||:. ||
  Rat   419 SSNSSKITVHFHSDHSYTDTGFLAEYLSYDSNDPCPGMFMCKTGRCIRKDLRC-DGWADCPDYSD 482

  Fly    97 ERYCRMGQVNRI---SNFQTMAF-----------------------AYYSSS----PQTQQ---- 127
            ||:||....::.   :.|....|                       ::..|:    ||:||
  Rat   483 ERHCRCNATHQFMCKNQFCKPLFWVCDSVNDCGDGSDEEGCSCPAGSFKCSNGKCLPQSQQCNGK 547

  Fly   128 ----------------------------------------RSRLNCQAVARPAPCDCGW-SFPN- 150
                                                    ..:.:|...:....||||. ||..
  Rat   548 DDCGDGSDEASCDNVNAVSCTKYTYRCQNGLCLNKGNPECDGKKDCSDGSDEKNCDCGLRSFTKQ 612

  Fly   151 -RIANGVEAGKHEFPSMVGLRDLSSNLPIFCGGSIVSERYIMTAAHCTARQPV-----ASRLLAL 209
             |:..|..|.:.|:|..|.|..|...  ..||.|::|..::::||||...:.:     .:...|.
  Rat   613 ARVVGGTNADEGEWPWQVSLHALGQG--HLCGASLISPDWLVSAAHCFQDETIFKYSDHTMWTAF 675

  Fly   210 VGEHDLSTGAESIYAAQYRIQNIINHPGYMETASGNINDIALLQTATPIEWSRGVAPICLPIRQA 274
            :|..|.|..:.| ...:::::.||.||.:.:....  .|||||:...|.|:|..|.|||||
  Rat   676 LGLLDQSKRSAS-GVQEHKLKRIITHPSFNDFTFD--YDIALLELEKPAEYSTVVRPICLP---- 733

  Fly   275 ENSFNY---QNVDIMGWGTLGFAASKSNTLQKATLLTMDNAVCRSRFNSSITPSHLCTYDAGGRG 336
            :|:..:   :.:.:.|||......:.:..|||..:..::...|.......|||..:|.....| |
  Rat   734 DNTHVFPAGKAIWVTGWGHTKEGGTGALILQKGEIRVINQTTCEELLPQQITPRMMCVGFLSG-G 797

  Fly   337 QDSCQYDSGGPVILRQRE-RMFQLGVISYGRACGQPFGIGVNTRVTSHLNWLWRYIG 392
            .||||.|||||:...::: |:||.||:|:|..|.|....||.||:....:|:....|
  Rat   798 VDSCQGDSGGPLSSVEKDGRIFQAGVVSWGEGCAQRNKPGVYTRIPEVRDWIKEQTG 854

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30375	NP_724665.1	CUB	38..>100	CDD:294042	26/132 (20%)
		Tryp_SPc	151..386	CDD:214473	75/243 (31%)
		Tryp_SPc	152..387	CDD:238113	74/243 (30%)
St14	NP_446087.1	SEA	88..178	CDD:396113
		CUB	214..332	CDD:238001
		CUB	340..444	CDD:238001	18/89 (20%)
		LDLa	454..486	CDD:238060	8/32 (25%)
		LDLa	492..523	CDD:238060	2/30 (7%)
		LDLa	525..559	CDD:238060	5/33 (15%)
		LDLa	567..602	CDD:238060	1/34 (3%)
		Tryp_SPc	615..852	CDD:238113	75/246 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	145	1.000	Inparanoid score	I4333
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.050