DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30350 and Nphs1

DIOPT Version :9

Sequence 1:	NP_724715.1	Gene:	CG30350 / 246556	FlyBaseID:	FBgn0050350	Length:	369	Species:	Drosophila melanogaster
Sequence 2:	NP_072150.1	Gene:	Nphs1 / 64563	RGDID:	620460	Length:	1252	Species:	Rattus norvegicus

Alignment Length:	175	Identity:	43/175 - (24%)
Similarity:	64/175 - (36%)	Gaps:	57/175 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 WHQ---HRERIKGAISTVDAEAPNFQAARITGVNNLRDEAQTFMKRTKANIQLLVEISRTMRTHG 118
            :||   |...:  .|:.|.| |.::...:.|..|.|..:        ..||| ||.|||.....|
  Rat   908 YHQGVVHSSLL--TIANVSA-AQDYALFKCTATNALGSD--------HTNIQ-LVSISRPDPPLG 960

  Fly   119 ----AINP--------------------FRYDTVHAVSSIPMALL-------TLEKLERDNRDFG 152
                :|:|                    .||:.:.....:.:.:|       ||..|:...| :.
  Rat   961 LKVVSISPHSVGLEWKPGFDGGLPQRFQIRYEALETPGFLHVDVLPTQATTFTLTGLKPSTR-YR 1024

  Fly   153 RRILEVNSEVDSGLSDKRMR-----EGRSSTP-----VAPLELPP 187
            ..:|..|:..||||:||.::     .|....|     ..|.||||
  Rat  1025 IWLLASNALGDSGLTDKGIQVSVTTPGPDQAPEDTDHQLPTELPP 1069

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30350	NP_724715.1	KIAA1430	60..155	CDD:290590	26/125 (21%)
CG30350	NP_724715.1	cyclophilin	212..369	CDD:294131
Nphs1	NP_072150.1	Ig	52..128	CDD:299845
		IG_like	52..127	CDD:214653
		C2-set_2	155..242	CDD:285423
		Ig_3	256..335	CDD:290638
		IG_like	268..350	CDD:214653
		C2-set_2	358..440	CDD:285423
		I-set	460..555	CDD:254352
		Ig	472..555	CDD:299845
		Ig	563..646	CDD:299845
		IG_like	670..750	CDD:214653
		Ig	676..750	CDD:299845
		Ig_3	753..834	CDD:290638
		IG_like	762..848	CDD:214653
		Ig	848..956	CDD:299845	18/59 (31%)
		IG_like	859..949	CDD:214653	13/52 (25%)
		FN3	955..1049	CDD:238020	18/94 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1043..1067		3/23 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1113..1144
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3515
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900