DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30350 and PPIL2

DIOPT Version :9

Sequence 1:	NP_724715.1	Gene:	CG30350 / 246556	FlyBaseID:	FBgn0050350	Length:	369	Species:	Drosophila melanogaster
Sequence 2:	XP_011528343.1	Gene:	PPIL2 / 23759	HGNCID:	9261	Length:	616	Species:	Homo sapiens

Alignment Length:	304	Identity:	55/304 - (18%)
Similarity:	110/304 - (36%)	Gaps:	42/304 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 AISTVDAEAPNFQAARITGVNNLRDEAQTFMKRT---KANIQLLVEISRTMRTHGAINPFRYDTV 128
            |:..::.:|.||:.. :|.....|.:..|....|   |.|:.....:...|:   .|:|   |..
Human   130 AVEQLNIKAKNFRDL-LTDEPFSRQDIITLQDPTNLDKFNVSNFYHVKNNMK---IIDP---DEE 187

  Fly   129 HAVSSIPMALL------TLEKLERDNRDF-GRRILEV------NSEVDSGLSDKRMREGRSSTPV 180
            .|... |...|      |.|.|:...::| |..||..      ..:||. |:......|:.|...
Human   188 KAKQD-PSYYLKNTNAETRETLQELYKEFKGDEILAATMKAPEKKKVDK-LNAAHYSTGKVSASF 250

  Fly   181 APLELPPQAMAKYEAFNIPLPKSDAELRRLFRPRIYFDLYLKDARPLGRFVVQLYTEAAPLVVLQ 245
            ....:.|:...:..|.:     .|....:..:.:.|..|:...    |...::|:.:..|.....
Human   251 TSTAMVPETTHEAAAID-----EDVLRYQFVKKKGYVRLHTNK----GDLNLELHCDLTPKTCEN 306

  Fly   246 LIKSCMCNQHSKFMVKRLFPNLWLE----TDLMLSSDSLLHQPLEYDAKV-IDHGASSYVLSFSK 305
            .|:.|..:.:...:..|...|..::    |......:|...:|.:.:.:. :.|.... :||.:.
Human   307 FIRLCKKHYYDGTIFHRSIRNFVIQGGDPTGTGTGGESYWGKPFKDEFRPNLSHTGRG-ILSMAN 370

  Fly   306 AYVTGFTHHLSFAISFKPLTVVNGSRVGFGRIVKGSKICECIQS 349
            :...  ::...|.|:|:....::.....|||:|.|..:...:::
Human   371 SGPN--SNRSQFFITFRSCAYLDKKHTIFGRVVGGFDVLTAMEN 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30350	NP_724715.1	KIAA1430	60..155	CDD:290590	22/97 (23%)
CG30350	NP_724715.1	cyclophilin	212..369	CDD:294131	23/143 (16%)
PPIL2	XP_011528343.1	RING-Ubox_PPIL2	38..110	CDD:319577
		RING_Ubox	100..159	CDD:388418	7/29 (24%)
		U-box domain, a modified RING finger	103..146	CDD:319361	4/16 (25%)
		cyclophilin_RING	281..440	CDD:238904	23/139 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0652
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900