DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG30345 and MFSD14B

DIOPT Version :9

Sequence 1:	NP_724760.2	Gene:	CG30345 / 246553	FlyBaseID:	FBgn0050345	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_115947.2	Gene:	MFSD14B / 84641	HGNCID:	23376	Length:	506	Species:	Homo sapiens

Alignment Length:	501	Identity:	110/501 - (21%)
Similarity:	201/501 - (40%)	Gaps:	111/501 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 SSWLK---RPRSLILEPAVFLVFF--GRFLTDAVYQNQILYQTCVTVMKYNATECEPFLGTDRAS 91
            |:||:   ||........:||.||  |...|..:   .:|::|                    .|
Human    34 STWLQGFGRPSVYHAAIVIFLEFFAWGLLTTPML---TVLHET--------------------FS 75

  Fly    92 DEVKKIEGQVQEYASTITMISSMLESTVPAIVSLFLGPWSDKFGRRPILLSTFTGYLFSAIILVV 156
            .....:.|.:|.....::.:|:.|           :|..||.:||:|.||.|    :|.....:.
Human    76 QHTFLMNGLIQGVKGLLSFLSAPL-----------IGALSDVWGRKPFLLGT----VFFTCFPIP 125

  Fly   157 LTQITTAVNISPWW-FLLSSVPSVFSGGTCALITILYCYVSDVATENKRAMRMVTMEAALGLGMM 220
            |      :.||||| |.:.||..|||    ...::::.||:||..|::|:.....:.|.....::
Human   126 L------MRISPWWYFAMISVSGVFS----VTFSVIFAYVADVTQEHERSTAYGWVSATFAASLV 180

  Fly   221 AGGVASGYIYAATGASILFILVGSIISIA-LLYVYFFVAESL--KSEDLETGSRIREFFRLDLVK 282
            :......|:.|:.|.| |.:||.:::::. :.::...|.|||  |...:..|::| .:.:.|...
Human   181 SSPAIGAYLSASYGDS-LVVLVATVVALLDICFILVAVPESLPEKMRPVSWGAQI-SWKQADPFA 243

  Fly   283 VLVKTCIRKRENYDRAIIWFVMMSLTLCVFAMEGESTVNYMFMRKQFDYTVQDYSVFNAARVVIQ 347
            .|      |:...|..:: .:.:::.|......|:.:..::::|:...:.....:.|.|...::.
Human   244 SL------KKVGKDSTVL-LICITVFLSYLPEAGQYSSFFLYLRQVIGFGSVKIAAFIAMVGILS 301

  Fly   348 VVGSTIAMILLRRLLGLSTIMMTLLAFACCVLESTVRATAVYGSE---MYLALMVGMMRGVMSPM 409
            :|..|..:.:|.|.||....::..|.|....|     |...:||:   |:.|..|..|..:..|.
Human   302 IVAQTAFLSILMRSLGNKNTVLLGLGFQMLQL-----AWYGFGSQAWMMWAAGTVAAMSSITFPA 361

  Fly   410 CKAILSHVTPSSELGKIFSLTTSLQSI-SPLGAAPLYTAVYQ----------------------A 451
            ..|::|....|.:.|....:.|.::.: :.||.| ||..::.                      |
Human   362 ISALVSRNAESDQQGVAQGIITGIRGLCNGLGPA-LYGFIFYMFHVELTELGPKLNSNNVPLQGA 425

  Fly   452 TVNFYPGIFNFISVGLYFLCFCMSAAVF--------GIQKSMGSNS 489
            .:...|.:|....|.:.||     .|:|        |:||...|:|
Human   426 VIPGPPFLFGACIVLMSFL-----VALFIPEYSKASGVQKHSNSSS 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30345	NP_724760.2	MFS_1	102..437	CDD:284993	77/342 (23%)
CG30345	NP_724760.2	MFS	121..472	CDD:119392	85/380 (22%)
MFSD14B	NP_115947.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25
		MFS	48..450	CDD:119392	100/469 (21%)
		MFS_1	49..394	CDD:284993	88/406 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	457..481		5/10 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2816
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D763423at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820