DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30345 and Mfsd14b

DIOPT Version :9

Sequence 1:	NP_724760.2	Gene:	CG30345 / 246553	FlyBaseID:	FBgn0050345	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_001077370.1	Gene:	Mfsd14b / 66631	MGIID:	1913881	Length:	507	Species:	Mus musculus

Alignment Length:	541	Identity:	120/541 - (22%)
Similarity:	209/541 - (38%)	Gaps:	125/541 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPRDDEEPIIGADDEPLDIEVRSPP----PSNR-----TFSSWLK---RPRSLILEPAVFLVFF- 52
            |..|.|.|     :||....|.||.    |..|     ...|||:   .|........:||.||
Mouse     1 MSTDGESP-----EEPRWKAVASPKASTMPEKRGSAQAASGSWLQGFGHPSVYHAAFVIFLEFFA 60

  Fly    53 -GRFLTDAVYQNQILYQTCVTVMKYNATECEPFLGTDRASDEVKKIEGQVQEYASTITMISSMLE 116
             |...|..:   .:|::|...         ..||           :.|.:|.....::.:|:.|
Mouse    61 WGLLTTPML---TVLHETFPQ---------HTFL-----------MNGLIQGVKGLLSFLSAPL- 101

  Fly   117 STVPAIVSLFLGPWSDKFGRRPILLSTFTGYLFSAIILVVLTQITTAVNISPWWFL-LSSVPSVF 180
                      :|..||.:||:|.||.|    :|.....:.|      :.|:|||:. :.||..||
Mouse   102 ----------IGALSDVWGRKPFLLGT----VFFTCFPIPL------MRINPWWYFGMISVSGVF 146

  Fly   181 SGGTCALITILYCYVSDVATENKRAMRMVTMEAALGLGMMAGGVASGYIYAATGASILFILVGSI 245
            |    ...::::.||:|...|::|:.....:.|.....:::......|:.|..|.| |.:||.::
Mouse   147 S----VTFSVIFAYVADFTQEHERSTAYGWVSATFAASLVSSPAIGTYLSANYGDS-LVVLVATL 206

  Fly   246 ISIA-LLYVYFFVAESL--KSEDLETGSRIREFFRLDLVKVLVKTCIRKRENYDRAIIWFVMMSL 307
            :::. :.::...|.|||  |......|::| .:.:.|....|      |:...|..:: .:.:::
Mouse   207 VALLDICFILIAVPESLSEKIRPASWGAQI-SWKQADPFASL------KKVGKDSTVL-LICITV 263

  Fly   308 TLCVFAMEGESTVNYMFMRKQFDYTVQDYSVFNAARVVIQVVGSTIAMILLRRLLGLSTIMMTLL 372
            .|......|:.:..::::|:...:.......|.|...::.:|..|:.:..|.|.||....::..|
Mouse   264 FLSYLPEAGQYSSFFLYLRQVIGFGSVKIVAFIAMVGILSIVAQTVFLSKLMRSLGNKNTVLLGL 328

  Fly   373 AFACCVLESTVRATAVYGSE---MYLALMVGMMRGVMSPMCKAILSHVTPSSELGKIFSLTTSLQ 434
            .|....|     |...:||:   |:.|..|..|..:..|...|::|....|.:.|....:.|.::
Mouse   329 GFQMLQL-----AWYGFGSQAWMMWAAGTVAAMSSITFPAVSALISRNAESDQQGVAQGIVTGIR 388

  Fly   435 SI-SPLGAAPLYTAVYQ----------ATVN---------FYPG---IFNFISVGLYFLCFCMSA 476
            .: :.||.| ||..::.          ..:|         |.||   :|....|.:.||     .
Mouse   389 GLCNGLGPA-LYGFIFYMFHVELSELGPKLNSDDDPLQGAFIPGPPFLFGACIVLMSFL-----V 447

  Fly   477 AVF--------GIQKSMGSNS 489
            |:|        |:||...|.|
Mouse   448 ALFIPEYRKTSGVQKHNNSTS 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30345	NP_724760.2	MFS_1	102..437	CDD:284993	74/342 (22%)
CG30345	NP_724760.2	MFS	121..472	CDD:119392	84/380 (22%)
Mfsd14b	NP_001077370.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27		10/30 (33%)
		MFS_MFSD14	47..452	CDD:340945	100/472 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	459..483		5/10 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2816
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D763423at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820