DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30345 and Mfsd14b

DIOPT Version :9

Sequence 1:	NP_724760.2	Gene:	CG30345 / 246553	FlyBaseID:	FBgn0050345	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_001100804.1	Gene:	Mfsd14b / 306687	RGDID:	1308377	Length:	507	Species:	Rattus norvegicus

Alignment Length:	537	Identity:	118/537 - (21%)
Similarity:	213/537 - (39%)	Gaps:	117/537 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPRDDEEPIIGADDEPLDIEVRSPP----PSNR-----TFSSWLKRPRSLILEPAVFLVFFGRFL 56
            |..|.|.|     :||....|.||.    |..|     ..||||:......:..|.|::||..|.
  Rat     1 MSTDGESP-----EEPGWKAVASPKASAMPEKRGSAQAASSSWLQGFGQPSVYHAAFVIFFEFFA 60

  Fly    57 TDAVYQNQILYQTCVTVMKYNATECEPFLGTDRASDEVKKIEGQVQEYASTITMISSMLESTVPA 121
            ..      :|....:||: :.......||           :.|.:|.....::.:|:.|
  Rat    61 WG------LLTTPMLTVL-HETFPQHTFL-----------MNGLIQGVKGLLSFLSAPL------ 101

  Fly   122 IVSLFLGPWSDKFGRRPILLSTFTGYLFSAIILVVLTQITTAVNISPWWFL-LSSVPSVFSGGTC 185
                 :|..||.:||:|.||.|    :|.....:.|      :.|||||:. :.||..|||
  Rat   102 -----IGALSDVWGRKPFLLGT----VFFTCFPIPL------MRISPWWYFGMISVSGVFS---- 147

  Fly   186 ALITILYCYVSDVATENKRAMRMVTMEAALGLGMMAGGVASGYIYAATGASILFILVGSIISIA- 249
            ...::::.||:|...|::|:.....:.|.....:::......|:.:..|.| |.:||.:::::.
  Rat   148 VTFSVIFAYVADFTQEHERSTAYGWVSATFAASLVSSPAIGTYLSSNYGDS-LVVLVATVVALLD 211

  Fly   250 LLYVYFFVAESL--KSEDLETGSRIREFFRLDLVKVLVKTCIRKRENYDRAIIWFVMMSLTLCVF 312
            :.::...|.|||  |......|::| .:.:.|....|      |:...|..:: .:.:::.|...
  Rat   212 ICFILVAVPESLPEKIRPASWGAQI-SWKQADPFASL------KKVGKDSTVL-LICITVFLSYL 268

  Fly   313 AMEGESTVNYMFMRKQFDYTVQDYSVFNAARVVIQVVGSTIAMILLRRLLGLSTIMMTLLAFACC 377
            ...|:.:..::::|:...:.......|.|...::.::..|:.:..|.|.||....::..|.|...
  Rat   269 PEAGQYSSFFLYLRQVIGFGSVKIVAFIAMVGILSILAQTVFLSKLMRSLGNKNTVLLGLGFQIL 333

  Fly   378 VLESTVRATAVYGSE---MYLALMVGMMRGVMSPMCKAILSHVTPSSELGKIFSLTTSLQSI-SP 438
            .|     |...:|::   |:.|..|..|..:..|...|::|....|.:.|....:.|.::.: :.
  Rat   334 QL-----AWYGFGAQAWMMWAAGTVAAMSSITFPAVSALISRNAESDQQGVAQGIITGIRGLCNG 393

  Fly   439 LGAAPLYTAV---YQATVN----------------FYPG---IFNFISVGLYFLCFCMSAAVF-- 479
            ||.| ||..:   :...:|                |.||   :|....|.:.||     .|:|
  Rat   394 LGPA-LYGFIFYLFHVELNELGPKLDSDNDPLQGAFIPGPPFLFGACIVLMSFL-----VALFIP 452

  Fly   480 ------GIQKSMGSNSV 490
                  |:||.  :||:
  Rat   453 EYRKTGGVQKH--NNSI 467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30345	NP_724760.2	MFS_1	102..437	CDD:284993	72/342 (21%)
CG30345	NP_724760.2	MFS	121..472	CDD:119392	82/380 (22%)
Mfsd14b	NP_001100804.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22		9/25 (36%)
		MFS_MFSD14	47..452	CDD:340945	98/467 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	462..483		3/8 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2816
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D763423at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820