DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30345 and SLC46A3

DIOPT Version :9

Sequence 1:	NP_724760.2	Gene:	CG30345 / 246553	FlyBaseID:	FBgn0050345	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_001129391.1	Gene:	SLC46A3 / 283537	HGNCID:	27501	Length:	463	Species:	Homo sapiens

Alignment Length:	470	Identity:	111/470 - (23%)
Similarity:	200/470 - (42%)	Gaps:	85/470 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 LILEPAVFLVFFGRFLTDAVYQNQILYQTCVTVMKY------NATECEPFLGTDRASDEVKKIEG 99
            |.:|||:||..|...||..:....:..:.......|      |.:|||     ...|..:...:.
Human     4 LFVEPAIFLSAFAMTLTGPLTTQYVYRRIWEETGNYTFSSDSNISECE-----KNKSSPIFAFQE 63

  Fly   100 QVQEYASTITM---ISSMLESTVPAIVSLF-LGPWSDKFGRR-PILLSTFTGYLFSAIILVVLTQ 159
            :||:..|...:   ||.:    :|.:||.| |...||.:||: |::||: .|.|.:::.|.:|..
Human    64 EVQKKVSRFNLQMDISGL----IPGLVSTFILLSISDHYGRKFPMILSS-VGALATSVWLCLLCY 123

  Fly   160 ITTAVNISPWWFLLSSVPSVFSGGTCALITIL----YCYVSDVATENK-RAMRMVTMEAALGLGM 219
            ..     .|:..|::   |.|.|..|...|..    :.|:.|...|:| :.:|:..::..|||..
Human   124 FA-----FPFQLLIA---STFIGAFCGNYTTFWGACFAYIVDQCKEHKQKTIRIAIIDFLLGLVT 180

  Fly   220 MAGGVASGYIYAATGASILFILVGSIISIALLYVYFFVAESLK-----------SEDLETGSRIR 273
            ...|::|||.....|....|:::...:::.|:|:.||:.:.:|           ||..:     .
Human   181 GLTGLSSGYFIRELGFEWSFLIIAVSLAVNLIYILFFLGDPVKECSSQNVTMSCSEGFK-----N 240

  Fly   274 EFFRLDLVKVLVKTCIRKRENYDRAIIWFVMMSLTLCVFAMEGESTVNYMFMRKQFDYTVQDYSV 338
            .|:|   ..:|.|....||    |.::..::.::....|.:.|.:.:   |:..:.|..:....|
Human   241 LFYR---TYMLFKNASGKR----RFLLCLLLFTVITYFFVVIGIAPI---FILYELDSPLCWNEV 295

  Fly   339 F-------NAARVVIQVVGSTIAMILLRRL----LGLSTIM--MTLLAFACCVLESTVRATAVYG 390
            |       .:|..:...:|..:....:..:    :|:.|.|  |.:.|||...|
Human   296 FIGYGSALGSASFLTSFLGIWLFSYCMEDIHMAFIGIFTTMTGMAMTAFASTTL----------- 349

  Fly   391 SEMYLALMVGMMRGVMSPMCKAILSHVTPSSELGKIFSLTTSLQSISPLGAAPLYTAVYQATVNF 455
             .|:||.:..:...|...:.:::||.|..|:|.|.:|:....|:::..:.|...:..:|.|||.:
Human   350 -MMFLARVPFLFTIVPFSVLRSMLSKVVRSTEQGTLFACIAFLETLGGVTAVSTFNGIYSATVAW 413

  Fly   456 YPGIFNFISVGLYFL 470
            |||....:|.||..|
Human   414 YPGFTFLLSAGLLLL 428

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30345	NP_724760.2	MFS_1	102..437	CDD:284993	83/368 (23%)
CG30345	NP_724760.2	MFS	121..472	CDD:119392	90/381 (24%)
SLC46A3	NP_001129391.1	MFS_1	81..399	CDD:311564	79/357 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	102	1.000	Domainoid score	I6826
eggNOG	1	0.900	-	-		E1_KOG2816
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	119	1.000	Inparanoid score	I4780
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48502
OrthoDB	1	1.010	-	-		D333052at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8463
orthoMCL	1	0.900	-	-		OOG6_100739
Panther	1	1.100	-	-	O	PTHR23507
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X552
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.880