DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30344 and YJL163C

DIOPT Version :9

Sequence 1:	NP_724759.1	Gene:	CG30344 / 246552	FlyBaseID:	FBgn0050344	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	NP_012372.1	Gene:	YJL163C / 853276	SGDID:	S000003699	Length:	555	Species:	Saccharomyces cerevisiae

Alignment Length:	578	Identity:	114/578 - (19%)
Similarity:	212/578 - (36%)	Gaps:	147/578 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 RSDTEALVADV-ETGEDS-------APRILDASSAASSEQVDPPPVPPPHDYSSYRWFILEPAVF 59
            ::|:..:..|. ||.:||       :|.||..:.:...|            :...:...|...|.
Yeast    34 QNDSTGINLDTNETAQDSSYDSIRRSPSILSVAKSVEGE------------HGRRKLLCLYGLVM 86

  Fly    60 LIFFARNLIGAVYQNQILYQTCITIEKFNATQCEPLL------GI-DRGSDADKEVEVIVQTYSA 117
            :|                   ||. |..:.|...||:      || |.....|   .|.|||..:
Yeast    87 II-------------------CIA-ESISMTATIPLVMDKVAEGISDENGHYD---SVAVQTIVS 128

  Fly   118 NIMMTTSLLESIIPAFASLFLGPWSDKFGRRPILLTTFTGYLTGALILIVITYI-TRSTNIS--P 179
            :|..:|.::...|..|.:...|..||:.||..:.     .|::|..::.::|:: |.|:.:.  .
Yeast   129 SISSSTMMIAGAISIFMAGKWGELSDRIGRVRVF-----KYMSGIRVIGLLTHVFTLSSKMKYHK 188

  Fly   180 WWFLLSS--VPSVVSGGTCALITGIYCYISDVAKERKKALRMVLNEASLCAGIMVGNVASGYIYA 242
            |..:|::  |||.  ||..||:.....|:||:.|...:.:.:.:..:.:.|.:.||.:...::..
Yeast   189 WAIVLTACIVPSF--GGLFALVANGNSYVSDIVKTEHRMVTIGIMMSCIYATMGVGPMFGSFLVK 251

  Fly   243 ATNALVLFSIAGSLMMFALMYVLLFVPESLNPGDIH---------TGSRVREFFR---------- 288
            .|:......|..|:   |.:.:.|.:.|::.....|         |.::.||..|
Yeast   252 WTHGNGFIPIYTSI---AFVILALIICETIMVEPRHETQMAHSQSTYTKRREKLRSQSGSDDARN 313

  Fly   289 FDLVT----------DLIRTCFKRRPNFDRTIIWL------------TMIALTIA-IFDMEGEST 330
            :..||          ||:....|         :||            |:|.|.:. |..:.|.::
Yeast   314 YQSVTYGKFQIMRLMDLLAPVKK---------LWLKPDSAGSLVPRHTVILLIVLDILFVCGTTS 369

  Fly   331 ---VNYMFVQDKFNWTIKD----FSLFNASRIVIQIVGSIVGMLVLRRV---LKMSI-------- 377
               ...:|...::.|...:    .|:....|.|:.:|.|...:..|:|:   |..||
Yeast   370 CMPALILFSTYEYKWHAVELGYFISILGIGRGVVLLVVSPTLLYTLKRIYQHLNHSIDKIDIFCI 434

  Fly   378 -VTMAMLSLACCVL----ESTVRATAVYWQELYLGMTLGMMRGVMGPMCRAILSHVAPATEVGKI 437
             .:|.:::|:..|:    |.|..:..::       ..|..:.....|..::.:.........|::
Yeast   435 QFSMIVITLSLFVMIRFGEKTPTSMIIF-------ALLQALSAFCSPTLQSGIIKYTSKKHTGEM 492

  Fly   438 FALTTSMESVSPLGAAPLYTTVYKATLENYPGAFNFISAALYFVCYILIAVIFGIQKS 495
            |.....:.|...|...|:...:|.:|:...|..|.:|..:...|. ||:.....|.|:
Yeast   493 FGAMALVRSCVMLVIPPILLKLYGSTVSVNPSLFMYIPFSTSIVA-ILLTFFLRIYKN 549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30344	NP_724759.1	MFS	113..490	CDD:119392	87/446 (20%)
CG30344	NP_724759.1	MFS_1	128..448	CDD:284993	73/389 (19%)
YJL163C	NP_012372.1	MFS	139..545	CDD:421695	83/432 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344976
Domainoid	1	1.000	56	1.000	Domainoid score	I2684
eggNOG	1	0.900	-	-		E1_KOG2816
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	74	1.000	Inparanoid score	I1664
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001349
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23507
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.890