DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30344 and Slc46a3

DIOPT Version :9

Sequence 1:	NP_724759.1	Gene:	CG30344 / 246552	FlyBaseID:	FBgn0050344	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	NP_001343931.1	Gene:	Slc46a3 / 71706	MGIID:	1918956	Length:	460	Species:	Mus musculus

Alignment Length:	487	Identity:	108/487 - (22%)
Similarity:	203/487 - (41%)	Gaps:	95/487 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 LEPAVFLIFFARNL---IGAVYQNQILYQTCITIEKFNATQCEPLLGIDRGSDADKEVEVIVQTY 115
            :|||:.|..||..|   :.|.|..:.:::     |..|.|    ......||:.|:.....:..:
Mouse     6 IEPAILLNAFAMTLTIPLTAQYVYRRIWE-----ETGNYT----FASNSNGSECDQNKSSSIFAF 61

  Fly   116 SANIMMTTSL------LESIIPAFASLF-LGPWSDKFGRR-PILLTTFTGYLTGAL--------- 163
            ...:....||      :.::||...|.| |...||..||: |::|::.     |:|
Mouse    62 REEVQKKASLFNLQVEMSALIPGLVSTFMLLASSDNHGRKLPMVLSSL-----GSLGTNTWLCMM 121

  Fly   164 --------ILIVITYI-TRSTNISPWWFLLSSVPSVVSGGTCALITGIYCYISDVAKERK-KALR 218
                    :||..|:| ....|.:.:|            |.|      :.||.|..||.| :.:|
Mouse   122 SYFDLPLQLLIASTFIGALFGNYTTFW------------GAC------FAYIVDQQKEYKHRIIR 168

  Fly   219 MVLNEASLCAGIMVG--NVASGYIYAATNALVLFSIAGSLMMFALMYVLLFVPESLNPGDIHTGS 281
            :.:.:..|  |::.|  .::|||.......:..:.|...:::..|.|:|.|:.:.:.    .:.|
Mouse   169 IAILDFML--GVVTGLTGLSSGYFIRELGFVWSYFITAMVLIVNLAYILFFLNDPIK----ESSS 227

  Fly   282 RVREFFRFDLVTDLI-RT--CFKRRPNFDRTIIWLTMIALTIAIFDMEGESTVNYMF-VQDKFNW 342
            ::......:.:.||. ||  .||...:..:.::.|.:..|.|..|.:.|.|.:..:: :.....|
Mouse   228 QIVTMSCIESLKDLFYRTYMLFKNGSSKRQALLCLLIFTLVIYFFVIIGISPIFTLYELGPPLCW 292

  Fly   343 TIKDFSLFNASRIVIQIVGSIVGMLVLRRVLK------MSI-VTMAMLSLACCVLESTVRATAVY 400
            . :.:..:.::...:..:.|.:|:.:....||      :.| .||..::|| ....:|:....|.
Mouse   293 N-EVYIGYGSALGSVSFLSSFLGIWLFSYCLKDIHIAYIGIFTTMVGMTLA-AFTRTTLMMFLVR 355

  Fly   401 WQELYLGMTLGMMRGVMGPMCRAILSHVAPATEVGKIFALTTSMESVSPLGAAPLYTTVYKATLE 465
            ...::..|.|.::        |::||.|..:||.|.:||....:|:::.:.:...|:.:|.||:.
Mouse   356 IPFIFTIMPLSVL--------RSMLSKVVHSTEQGALFACIAFLETLAGVTSTSAYSGIYSATVA 412

  Fly   466 NYPGAFNFISAALYFVCYILIAVIFGIQKSMG 497
            .|||....:||.|    .:|.|:.....||:|
Mouse   413 WYPGFIFLLSAGL----LVLPAISLCCVKSIG 440

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30344	NP_724759.1	MFS	113..490	CDD:119392	90/416 (22%)
CG30344	NP_724759.1	MFS_1	128..448	CDD:284993	76/353 (22%)
Slc46a3	NP_001343931.1	MFS	3..437	CDD:391944	105/482 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	70	1.000	Domainoid score	I9497
eggNOG	1	0.900	-	-		E1_KOG2816
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	122	1.000	Inparanoid score	I4732
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48502
OrthoDB	1	1.010	-	-		D333052at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8701
orthoMCL	1	0.900	-	-		OOG6_100739
Panther	1	1.100	-	-	O	PTHR23507
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X552
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.880