DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30340 and Prlhr

DIOPT Version :9

Sequence 1:	NP_724812.2	Gene:	CG30340 / 246550	FlyBaseID:	FBgn0050340	Length:	396	Species:	Drosophila melanogaster
Sequence 2:	NP_963909.2	Gene:	Prlhr / 226278	MGIID:	2135956	Length:	370	Species:	Mus musculus

Alignment Length:	332	Identity:	91/332 - (27%)
Similarity:	147/332 - (44%)	Gaps:	64/332 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 LHKPNGEITWKICTFLPLIAFGLYGNFSMVYVIATNRSLRSPTNLIIANMAVADLLTLAICPAMF 88
            :|:..|.|   :..:..::..||.||..:|.|||..|.|.:.||.:|.|:|::|:|..|.|..:.
Mouse    56 VHQLKGLI---VMLYSIVVVVGLVGNCLLVLVIARVRRLHNVTNFLIGNLALSDVLMCAACVPLT 117

  Fly    89 MVNDFY-QNYQLGCVGCKLEGFLVVVFLITAVLNLSVVSYDRLTAIVLPMETRLTIRGVQIVVVC 152
            :...|. :.:..|...|.|..||..|.:..:|..|:.::.||...:|.|:..|:::|.....|:.
Mouse   118 LAYAFEPRGWVFGGGLCHLVFFLQPVTVYVSVFTLTTIALDRYVVLVHPLRRRISLRLSAYAVLG 182

  Fly   153 TWVSGILLASPLAFYRSYRVRVWKNFTERYCKENTSVLPKYW-------------YVLITILVWL 204
            .|....:||.|.|.: :|.|.: |......|:|       :|             .:|.|.|  |
Mouse   183 IWALSAVLALPAAVH-TYHVEL-KPHDVSLCEE-------FWGSQERQRQIYAWGLLLGTYL--L 236

  Fly   205 PLGIMLICYIAIFYKLDRYEKRVLSRENPLTVSY---------KRSVAKTLFIVVVVFAALRLPF 260
            ||..:|:.|:.:..||   ..||:    |.:|:.         :|.....|.:||||||...||.
Mouse   237 PLLAILLSYVRVSVKL---RNRVV----PGSVTQSQADWDRARRRRTFCLLVVVVVVFAVCWLPL 294

  Fly   261 TILVVLR-------EKY-FGEDVSVSSGMQLFWYISQYLMFLNAAVNPLIYGFNNENFRRAYYQ- 316
            .|..:||       :.| ||          |...:..:|...:|..||.||.:.:::||....:
Mouse   295 HIFNLLRDLDPRAIDPYAFG----------LVQLLCHWLAMSSACYNPFIYAWLHDSFREELRKM 349

  Fly   317 -ISWVRR 322
             :||.|:
Mouse   350 LLSWPRK 356

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30340	NP_724812.2	7tm_4	44..315	CDD:304433	85/301 (28%)
CG30340	NP_724812.2	7tm_1	48..303	CDD:278431	79/285 (28%)
Prlhr	NP_963909.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..33
		7tmA_PrRP_R	61..346	CDD:320516	87/315 (28%)
		TM helix 1	62..88	CDD:320516	9/28 (32%)
		TM helix 2	95..120	CDD:320516	9/24 (38%)
		TM helix 3	134..164	CDD:320516	9/29 (31%)
		TM helix 4	175..196	CDD:320516	5/20 (25%)
		TM helix 5	222..251	CDD:320516	8/30 (27%)
		TM helix 6	271..301	CDD:320516	11/29 (38%)
		TM helix 7	314..339	CDD:320516	8/34 (24%)
		Required for interaction with GRIP1, GRIP2 and PICK1. /evidence=ECO:0000250	365..370
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24235
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.100