DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30340 and npr-5

DIOPT Version :9

Sequence 1:	NP_724812.2	Gene:	CG30340 / 246550	FlyBaseID:	FBgn0050340	Length:	396	Species:	Drosophila melanogaster
Sequence 2:	NP_001024265.1	Gene:	npr-5 / 190386	WormBaseID:	WBGene00021983	Length:	433	Species:	Caenorhabditis elegans

Alignment Length:	330	Identity:	68/330 - (20%)
Similarity:	139/330 - (42%)	Gaps:	49/330 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 ICTFLP--LIAFGLYGNFSMVYVIATNRSLRSPTNLIIANMAVADLL----TLAICPAMFMVNDF 93
            |.|||.  |...|::||..:::.:|.|:.|:|..|:.:.|:...||:    .:.:.|...|..|
Worm    57 IFTFLYGFLFVLGIFGNGGVLWAVARNKRLQSARNVFLLNLIFTDLILVFTAIPVTPWYAMTKD- 120

  Fly    94 YQNYQLGCVGCKLEGFLVVVFLITAVLNLSVVSYDRLTAIVLPMETRLTIRGVQIVVVCTWVSGI 158
               :..|.|.|.|........:.....:|:.:|.|:...|..|.:..::||....:....|:...
Worm   121 ---WAFGSVMCHLVPLSNSCSVFVTSWSLTAISLDKFLHINDPTKQPVSIRQALAITFLIWIVST 182

  Fly   159 LLASP--LAFYR---SYRVRVWKN-FTERYC------KENTSVLPKYWYVLITILVWLPLGIMLI 211
            |:..|  ::|..   |:.|:..:. :...:|      .||:..:  |...::.:...:|:.::..
Worm   183 LINLPYLMSFEHVDGSFYVQPGETPYCGHFCDEANWQSENSRKI--YGTTVMLLQFVVPMAVITY 245

  Fly   212 CYIAIFYKLDR--------YEKRVLSRENPLTVSYKRSVAKTLFIVVVVFAALRLPFTILVVLRE 268
            ||..|..|:.:        :.:.:..::.....|.|:.|...|..:||.|....||.|:|.::::
Worm   246 CYFKILQKVSKDMIIQNAQFCQSLTQKQRSDATSRKKKVNYILIAMVVTFIGCWLPLTLLNLVKD 310

  Fly   269 KYFGEDVSVSSGMQLFWYISQYLMFLNAAV-NPLIYGFNNENFRRAYYQISWVRRWRDATQMKKF 332
              |.::.........||.|:.:::.::..| |||::              .|:.|.:..:.:.|.
Worm   311 --FKKEPEWLKRQPFFWAINAHVIAMSLVVWNPLLF--------------FWLTRKQKRSGLSKI 359

  Fly   333 SRSPD 337
            ..|.:
Worm   360 LNSTE 364

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30340	NP_724812.2	7tm_4	44..315	CDD:304433	59/295 (20%)
CG30340	NP_724812.2	7tm_1	48..303	CDD:278431	58/279 (21%)
npr-5	NP_001024265.1	7tmA_NPYR-like	56..347	CDD:320331	64/311 (21%)
		TM helix 1	58..82	CDD:320331	7/23 (30%)
		TM helix 2	91..113	CDD:320331	4/21 (19%)
		TM helix 3	129..151	CDD:320331	2/21 (10%)
		TM helix 4	172..188	CDD:320331	2/15 (13%)
		TM helix 5	225..248	CDD:320331	3/24 (13%)
		TM helix 6	282..307	CDD:320331	9/24 (38%)
		TM helix 7	323..347	CDD:320331	7/37 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910