DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30338 and RWDD2A

DIOPT Version :9

Sequence 1:	NP_724811.1	Gene:	CG30338 / 246548	FlyBaseID:	FBgn0050338	Length:	288	Species:	Drosophila melanogaster
Sequence 2:	NP_219479.2	Gene:	RWDD2A / 112611	HGNCID:	21385	Length:	292	Species:	Homo sapiens

Alignment Length:	306	Identity:	95/306 - (31%)
Similarity:	147/306 - (48%)	Gaps:	49/306 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 EELQTYRRCVGLQLEELELLSSIYCAPGELHMLDAGVVADFNEFLKDDKTKPATSLLSHLEYVVK 68
            |.||       |||.|:|:|.|::...||:.:.|...:.:...:|:..:    .:|...:|:|:.
Human     7 ESLQ-------LQLLEMEMLFSMFPNQGEVKLEDVNALTNIKRYLEGTR----EALPPKIEFVIT 60

  Fly    69 LTL-PGKQCVEVRVELPHLYPLLEQARVSVHTTLLGKSKE-----QRLKN-DLEQYHGERREEDA 126
            |.: ..|..::::|.:||.||.       |...|.|:|.|     |.|.| .|..|.|  ..:..
Human    61 LQIEEPKVKIDLQVTMPHSYPY-------VALQLFGRSSELDRHQQLLLNKGLTSYIG--TFDPG 116

  Fly   127 EPYIFQLLSWLQDRIEDLLKRPASEFEVQQVA--SSDPQQPPATELQRIWIYSHHIKSSAKRQEL 189
            |..:...:.||||       ..||.|..:::.  .|...:|......|:|||||||.....|:::
Human   117 ELCVCAAIQWLQD-------NSASYFLNRKLVYEPSTQAKPVKNTFLRMWIYSHHIYQQDLRKKI 174

  Fly   190 IRQARQLELTGFSRPGKPGIICVEGDSANVQEFWRTIKALRWQKISVVRTEPRQRK------RGF 248
            :...::|::|||...||||||||||...:.:|||.||:...|:.||....|..:.:      |.|
Human   175 LDVGKRLDVTGFCMTGKPGIICVEGFKEHCEEFWHTIRYPNWKHISCKHAESVETEGNGEDLRLF 239

  Fly   249 EDFSEQLFNA--EEGV-----MNMGQFIRFLEAHGFGYMKSELFGL 287
            ..|.|.|..|  :.|:     ||:|||:.||:.|...::...|||:
Human   240 HSFEELLLEAHGDYGLRNDYHMNLGQFLEFLKKHKSEHVFQILFGI 285

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30338	NP_724811.1	DUF1115	175..>240	CDD:284060	29/64 (45%)
RWDD2A	NP_219479.2	RWD	15..134	CDD:214735	35/138 (25%)
RWDD2A	NP_219479.2	DUF1115	160..281	CDD:399506	45/120 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141475
Domainoid	1	1.000	76	1.000	Domainoid score	I8976
eggNOG	1	0.900	-	-		E1_28IR6
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H12315
Inparanoid	1	1.050	120	1.000	Inparanoid score	I4771
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53050
OrthoDB	1	1.010	-	-		D1387276at2759
OrthoFinder	1	1.000	-	-		FOG0004978
OrthoInspector	1	1.000	-	-		otm41157
orthoMCL	1	0.900	-	-		OOG6_103700
Panther	1	1.100	-	-	O	PTHR15955
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5060
SonicParanoid	1	1.000	-	-		X3514
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	16	15.840