Protein Alignment Vha100-3 and VPH1

DIOPT Version :9

• Sequence 1: NP_725837.1
• Gene: Vha100-3 / 246543
• FlyBaseID: FBgn0028669
• Length: 904
• Species: Drosophila melanogaster
• Sequence 2: NP_014913.3
• Gene: VPH1 / 854444
• SGDID: S000005796
• Length: 840
• Species: Saccharomyces cerevisiae
• Alignment Length: 932
• Identity: 277/932 - (29%)
• Similarity: 438/932 - (46%)
• Gaps: 157/932 - (16%)

  Fly    10 KVKSFFRSEDMDLCQLLLHTENAFDCLIEVGHHGAVQFNNVYDEDRLLNNLYSKKVTQCYELLRI 74
            |.::.|||.:|.|.|..:..|.:.|....:|..|.|||.::..:.|.....:..::.:    |..
Yeast     4 KEEAIFRSAEMALVQFYIPQEISRDSAYTLGQLGLVQFRDLNSKVRAFQRTFVNEIRR----LDN 64

  Fly    75 VDSLHTYIVQLHVNEIFYPDVDREN-RLKEKDLAKYSDSLKRIHVEAS-AVTEHYYR-------- 129
            |:..:.|         ||..:.:.: :|.|.|..||.|....::|..| :|.:.|.|
Yeast    65 VERQYRY---------FYSLLKKHDIKLYEGDTDKYLDGSGELYVPPSGSVIDDYVRNASYLEER 120

  Fly   130 ----------LDSRRNRMMEHSFALNKANKYMV-SDMGSELLYSESTVIGLVQDAT--TTSGAYP 181
                      ::.::|.:.::.|.|...:::.: .|......|.:..:|    ||.  ..:.|..
Yeast   121 LIQMEDATDQIEVQKNDLEQYRFILQSGDEFFLKGDNTDSTSYMDEDMI----DANGENIAAAIG 181

  Fly   182 AHLNYMIGCIRADKFYSFELLLYRLCSFNLIIRFSEMPSPVY-----EYHYGYKPERVRKFAILM 241
            |.:||:.|.|..||..:.|.:|:|:...||..:..|:..|||     ||.:        |.|.::
Yeast   182 ASVNYVTGVIARDKVATLEQILWRVLRGNLFFKTVEIEQPVYDVKTREYKH--------KNAFIV 238

  Fly   242 MASSTMIWPKVLKICAHYHVNIYDCPSSASQREDKVKELSQEIVNVEKVLKEAELMRRQILEVAG 306
            .:...:|..::.||......|:||..||...|..::.::::.:.::..|||.........|....
Yeast   239 FSHGDLIIKRIRKIAESLDANLYDVDSSNEGRSQQLAKVNKNLSDLYTVLKTTSTTLESELYAIA 303

  Fly   307 RDLFIIRVNLRKALKVYDLMNRLRLVGGVEVPRYLLAEVYIPSSDVPEVEVIL-RNASRISGGAD 370
            ::|.....::.:...:::::|:.......::   |:||.:||..::..::..| ...:|:  |.|
Yeast   304 KELDSWFQDVTREKAIFEILNKSNYDTNRKI---LIAEGWIPRDELATLQARLGEMIARL--GID 363

  Fly   371 NIDSSDEDEMNDMKTMPNTTPYPIEADFQPLEDMSAGAILLKKNRLVNHMPPTYFRLNKFTRGFQ 435
                                   :.:..|.|:              .||.|||:.|.||||.|||
Yeast   364 -----------------------VPSIIQVLD--------------TNHTPPTFHRTNKFTAGFQ 391

  Fly   436 NLIDAYGMADYKELNPAPYTIITFPFLFAVMFGDLGHGILLILFSSLMIWKHREIEKYQINATSE 500
            ::.|.||:|.|:|:|....||:||||:||:||||:|||.|:.|.:..::     :.:.:||....
Yeast   392 SICDCYGIAQYREINAGLPTIVTFPFMFAIMFGDMGHGFLMTLAALSLV-----LNEKKINKMKR 451

  Fly   501 NEILNILYAGRYIILLMGVFSVYMGLVYNIVMAKGFNLFGSSWSCRYNETTVYDPAFHVTLDSSH 565
            .||.::.:.||||||||||||:|.|.:||.:.:|...:|.|.|..                   .
Yeast   452 GEIFDMAFTGRYIILLMGVFSMYTGFLYNDIFSKTMTIFKSGWKW-------------------P 497

  Fly   566 PHFYSGH--------PYPLGMDPVWAVCG-QDSITTTNSLKMKMAIVLGISQMMFGLGLAAANCV 621
            .|:..|.        .||:|:|  ||..| ::::..:||.|||::|::|...|.:....:.||.:
Yeast   498 DHWKKGESITATSVGTYPIGLD--WAWHGTENALLFSNSYKMKLSILMGFIHMTYSYFFSLANHL 560

  Fly   622 LMNRKADLILVVIPQMIFMLCLFGYLVFLIFYK----WMSYGGHKPAPYNAACAPSVLITFINMM 682
            ..|...|:|...||.::||..:||||...|.||    |:..|  ||       ||.:|...|||.
Yeast   561 YFNSMIDIIGNFIPGLLFMQGIFGYLSVCIVYKWAVDWVKDG--KP-------APGLLNMLINMF 616

  Fly   683 LMKKEDPVENCLDYMYPNERMIEFALVGIAFCTIPILLAGKPIYLMRRRRKMQQERERDFKRMRR 747
            |  ....::   |.:||::..::..|:.:|...||.||..||::.....:|...|.....:....
Yeast   617 L--SPGTID---DELYPHQAKVQVFLLLMALVCIPWLLLVKPLHFKFTHKKKSHEPLPSTEADAS 676

  Fly   748 QTIAEMRSTMRYTDDDNSETSRQKSVDNEEEHEMSEIWIHSGIHTIETVLGSVSHTASYLRLWAL 812
            ....|.:..:...|.|::|.....|..:.|  :..:|.||..|||||..|..|||||||||||||
Yeast   677 SEDLEAQQLISAMDADDAEEEEVGSGSHGE--DFGDIMIHQVIHTIEFCLNCVSHTASYLRLWAL 739

  Fly   813 SLAHDQLSDVLWHMV--LTKGFANTLPLYYGVPVLMATFFAWAILTVAILVMMEGLSAFLHTLRL 875
            ||||.|||.|||.|.  :..||..    :.||.:.:|.|..|..||.|:||:|||.||.||:|||
Yeast   740 SLAHAQLSSVLWTMTIQIAFGFRG----FVGVFMTVALFAMWFALTCAVLVLMEGTSAMLHSLRL 800

  Fly   876 HWVEFQSKFFGGAGESFKAFNF 897
            ||||..||||.|.|..::.|.|
Yeast   801 HWVESMSKFFVGEGLPYEPFAF 822

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-3	NP_725837.1	V_ATPase_I	38..897	CDD:279793	267/902 (30%)
VPH1	NP_014913.3	V_ATPase_I	31..822	CDD:396194	267/903 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344192
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1269
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S598
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000328
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100301
Panther	1	1.100	-	-	O	PTHR11629
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.650